Animal Model Research

Request for Information (RFI)
Animal Model Research

General Information:

This is an RFI as defined in FAR 15.201(e) to ascertain whether a commercial item exists that provides the capabilities described herein.   

This RFI is issued solely for information and planning purposes and does not constitute a solicitation. All information received in response to this RFI will be treated as business confidential information.  Nonetheless, submitters should properly mark their responses if the information is confidential.  Responses to the RFI will not be returned.  Responses to this notice are not offers and cannot be accepted by the Government to form a binding contract.  Responders are solely responsible for all expense associated with responding to this RFI.

RFI Response and due date: 8 April 2022

Instructions to Responders:

Responses from all capable and qualified sources are encouraged to respond to this request.  

White papers should adhere to the following formatting and outline instructions:

1.   All submissions shall be made electronically and be in one of the following formats: Microsoft Word or Adobe PDF.

2. Cover Page (1page)
•    Title 
•    Organization
•    Responders technical and administrative points of contact (names, addresses, phone, fax number and email addresses)
•    Topic area(s) addressed
•    NAICS Code

3.   Interested parties are asked to respond to this RFI and submit a capabilities statement that supports the focus of this RFI as detailed below.  Please review the place of performance requirements. Please submit written responses via email in Microsoft Office 2000 or 2007 format.  All responses should be complete: in 12-point font; and not to exceed 3 pages total, including graphics, tables, and appendices.

No hardcopies shall be accepted. No written solicitation document is available at this time. Telephone requests will not be honored, and no bidders list shall be maintained. No inquiries regarding any potential future acquisition activities shall be entertained.

Potential offerors are requested to direct all questions via email to the Point of Contact listed below. Responses are due to the Point of Contact, Ms. Rebecca Wisner at email:  rebecca.c.wisner.civ@mail.mil  no later than 10:00AM ET, Friday, April 8, 2022. 

Requirement & Specification
Animal model research, using precise genome solutions to better understand human disease.

Contrator shall perform a Speed Expansion using imported cryopreserved wildtype(C3_cKO) noncarrier(Sox2-cre) homozygous(C3 recombined) (Stock# 409157) sperm and C57BL/6J (stock# 000664) oocytes. The resulting heterozygous mice will be intercrossed to generate a single shipment of 25-30 homozygous(C3 KO) male mice at 5 to 8 weeks of age.  

It is imperative that this model prevents cumulative genetic drift in these strains.

The deliverables will be 25-30 male mice with a whole body C3 gene knockout. Once the shipment is complete, the project will be concluded and removed within 4 weeks unless another change order is requested to extend the project.