6515--Liquid Chromatography Mass Spectrometer (LCMS )

Combined Synopsis-Solicitation for Commercial Items

VHAPM Part 813.106 SAP: Soliciting Competition & Evaluation of Quotations SOP Page 3 of 5

Original Date: 10/12/17

Revision 04 Date: 06/10/20

Description

This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in Federal Acquisition Regulation (FAR) subpart 12.6, Streamlined Procedures for Evaluation and Solicitation for Commercial Items, as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; quotes are being requested, and a written solicitation document will not be issued.

This solicitation is issued as an RFQ. The solicitation document and incorporated provisions and clauses are those in effect through Federal Acquisition Circular 2021-06 effective July 12, 2021.

The associated North American Industrial Classification System (NAICS) code for this procurement is 339112, with a small business size standard of 1,250 employees.

The FSC/PSC is 6515.

The Richard L. Roudebush Veterans' Administration Medical Center, 1481 West Tenth Street, Indianapolis, IN 46202 has a requirement for another liquid chromatography mass spectrometry(LCMS) equipment purchase.

All interested companies shall provide quotations for the following:

Supplies

Line Item

Description

Qty

Unit of Measure

Unit Price

Total Price

0001

SCL-40 with Installation Kit

1

EA

0002

DGU-405 5-channel Degasser

1

EA

0003

HPLC Startup Kit w/o Res Tray #1 2-GAL Poly

1

EA

0004

LC-40D XR UHPLC Pump

2

EA

0005

FCV-11AL Reservoir Selector

1

EA

0006

MiRC Mixer MR40 for pH 1-14

1

EA

0007

Piping Kit B, for High Pressure GE, ID0.1

1

EA

0008

SIL-40CXR with Installation Kit

1

EA

0009

Mobile Phase Monitor, Controller

1

EA

0010

A/C Adapter for Mobile Phase Monitor

1

EA

0011

Mobile Phase Monitor, Bottle Holder

3

EA

0012

CTO-40C Column Oven

1

EA

0013

FCV-0206H 2-position 6-port UHPLC Valve

2

EA

0014

FCV Piping Kit, 2 pc. (ID. 0.1)

1

EA

0015

UPS 5.2kVa, for LCMS, ABCDEF5202-22

1

EA

0016

LCMS-8060NX Package with Dry Pump Option

1

EA

0017

Peak Nitrogen and Air Generator Genius 1051 for LCMS-8045/8050/8060

1

EA

0018

LCMS-8045/8050/8060/9030 Installation Kit

1

EA

0019

Tier 4 Installation and Customer Familiarization

1

EA

0020

1 YEAR WARRANTY

1

EA

0021

LCMS-101: Introduction to LCMS Triple Quad Instrumentation

2

EA

Statement of Work

Liquid Chromatography Mass Spectrometry

Scope

The Richard L. Roudebush VA, Pathology and Laboratory Medicine Service, has a requirement for a liquid chromatography mass spectrometry(LCMS) equipment purchase.

The Toxicology department purchased our first LCMS five years ago in order to bring toxicology/urine drug testing in-house and save money by not sending samples out to contract labs. It is important for the Toxicology department to purchase a second LCMS as a back up to the original equipment and to provide the means to test more samples. The Toxicology department is in negotiations with VISN10 and the Cincinnati VAMC to run urine drug testing for their veterans. The second LCMS will enable us to run all samples, generate revenue from outside sources and expand our testing menu to better serve the veterans. This purchase must produce data and methods that are compatible with our current system (Shimadzu). The compatibility will allow us to maintain our Standard Operating Procedures without interrupting the continuity of care.

Contractor shall provide all equipment, accessories, installation, and training of the end users, offsite training for two personnel and a one-year warranty period. All equipment is to be new and state of the art, discontinued or used equipment will not be accepted. The instrumentation shall perform all analyses for the required tests with precision as defined by the 1988 Clinical Laboratory Improvement Act (CLIA) and the Clinical and Laboratory Standards Institute (CLSI, formerly NCCLS). The system must utilize ultra-high pressure (performance) liquid chromatography (UHPLC) or Ultra-Performance LC (UPLC) coupled with mass spectrometry to analyze and identify drugs of abuse in clinical samples such as serum, urine, and saliva samples.

UHPLC/UPLC-MS/MS Basic Equipment Specifications

Instrument must be a tandem quadrupole, liquid chromatography mass spectrometer system configured for integrated UHPLC or UPLC-MS/MS analysis with the following minimum specifications, features, and accessories:

1. General

The liquid chromatograph and the mass spectrometer must be part of a fully integrated system.

The liquid chromatograph and the mass spectrometer must be serviced by the manufacturer.

Integrated software should be able to operate both the MS and UHPLC/UPLC instruments from a single unified operating platform.

The system should be capable of performing both Qualitative and Quantitative analysis in a single run.

Manufacturer shall include, at no additional cost, installation, training, and technical support. Technical support shall include phone support, and on-site visits for follow up training.

The contractor shall provide all upgrades to the equipment hardware, software, and operating systems without additional charge to the Government. These enhancements to the contractor s equipment shall be delivered and installed at the site within 60 days of their issuance or date of first commercial availability. The contractor shall at all times maintain compatibility of systems with whatever host LIS or TCP/IP interface is in place, especially when contractor software is upgraded.

2. Mass Spectrometer Interface

The system shall be equipped with an electrospray ionization (ESI) source, heated to a maximum temperature of 400 degrees Celsius.

Ionization source maintenance must be performed without breaking MS vacuum.

To limit sensitivity loss from the elevated flow rates of UHPLC/UPLC, the ionization source design must allow for high efficiency ionization and desolvation at the high flow rates seen with UHPLC/UPLC. Designs should limit thermal degradation.

3. Mass Analyzer

High resolution main analyzer quadrupoles should have a pre-filter design to keep main rods clean and to focus ions in phase into the main quadrupoles.

Collision cell optimized for high speed data acquisition. Collision gas is Argon.

The detector should be high efficiency, high sensitivity, and wide dynamic range photomultiplier or electron multiplier detector. Detector operates in a digital counting mode. Performance specifications of the detector should be detailed for evaluation.

4. Tuning

System includes autotuning software functions.

Autotuning optimizes BOTH positive and negative ion modes automatically.

Autotuning optimizes all scan speeds automatically.

A single solution tuning standard is used for production of positive and negative ions for tuning purposes for ESI (Electrospray Ionization).

Autotune provides full automated tuning for mass axis calibration, sensitivity, and mass resolution.

5. Vacuum system

A single multiport turbo pump drives the entire LCMS instrument.

A single rotary (backing) pump drives the entire LCMS instrument.

6. Performance requirements

MS/MS acquisition modes should include product ion scan, precursor ion scan, neutral loss scan, multiple reaction monitoring (MRM).

MS acquisition modes should include selected ion monitoring/recording and full scan.

Polarity switching is completed in /= 10,000 atomic mass units (amu)/sec [Daltons (Da)/s].

Minimum dwell time is