Statement of Work.pdf

Statement of Work (SOW) Holstein Calves for use in BRSV Research

GENERAL INFORMATION

1.0 Scope of Work

In the current study, we propose to examine the duration of immunity induced by mucosal BRSV F/G nano-vaccination and to identify the immune responses that correlate with long-term resistance to BRSV infection. Thus, in these experiments, we will study how long a new vaccine protects young calves from disease.

2.0 Background

This study has important implications for both human and animal health. Bovine RSV is a major cause of lower respiratory tract infection in calves. There are currently no RSV vaccines approved for use in humans. Although commercial bovine RSV vaccines are available, there is also a need for bovine RSV vaccines with greater efficacy.

CONTRACTOR REQUIREMENTS

3.0 Technical Requirements for this purchase include:

• Breed – must be purebred Holstein breed calves to reduce the genetic variation due to breed and to allow direct comparison across planned related studies.

• Age – 2 months of age at the time of delivery. Date of Birth must be confirmed prior to arrival.

• Males shall be castrated and dehorned (healed) prior to arrival.

• Females shall not be bred.

• Calves must be weaned prior to arrival to the NCAH

• Animals shall be conventionally raised.

• Calves shall be sourced from the same farm.

• Source herd must be a Tuberculosis Free herd.

• Calves must be sourced from a farm within 100 miles of Ames to limit transport time of the animals on the trailer.

• Calves must be transported directly to NADC with no other

• animals in the trailer.

• 40 calves must be of comparable size across the group.

• All calves shall be confirmed ring worm free prior to arrival.

• All calves shall be confirmed pink eye free prior to arrival.

• All calves shall demonstrate no signs of clinical illness.

• All calves shall have sound legs and good eyes.

• A Certificate of Veterinary Inspection is required for all animals.

• Pre-Purchase blood work may be requested by the USDA anytime from the time of award until the arrival of animals to ensure vaccination titer levels.

• Communication with any possible vendor from the time of solicitation to the arrival of animals must be had between Animal Resources Unit in Ames and the possible vendor. This communication may include group or individual animal health status, pre-purchase blood work results, housing and feeding information that could be subject to change within this time frame.

• USDA personnel retain the right to reject calves determined to NOT satisfy health requirements anytime from the date of award through arrival onsite. The USDA retains the right to cancel the entire order if the vendor fails to provide the required number of animals that meet the required total number of animals.

• Quoted price can include transportation delivery costs but if it does NOT include transportation, quotes will be evaluated with that in mind.

• All calves must be available on or near mid-December 2023 at the age of 2 months.

SUPPORTING INFORMATION

4.0 Place of Delivery: USDA, 1920 Dayton Avenue, Ames, IA 50010

5.0 Technical Point of Contact: Denise Chapman: 515-337-7227

denise.chapman@usda.gov

GENERAL INFORMATION