combined synopsis solicitation.pdf

FDA-SOL-21-1237651: Center for Tobacco Products (CTP) ADMET or Equal Software License Renewal & Support

1. COMBINED SYNOPSIS/SOLICITATION: This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in FAR subpart 12.6, as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; proposals are being requested and a written solicitation will not be issued.

2. Date: February 2, 2021

3. Year 2021

4. Contracting Office Zip Code: 20705

5. Product or Service (PSC)Code: H270, Equipment and Materials Testing - Software.

The NAICS code for this requirement is 511210, Software Publishers. Small Business size standard: $38.5 million.

6. Contracting Office Address: Office of Acquisitions and Grants Services U.S. Food and Drug Administration 4011 Powder Mill Road, 4th Floor Beltsville, MD 20705

7. Subject: CTP ADMET Software License Renewal

8. Solicitation Number: FDA-SOL-21-1237651

9. Quotes Due By: Wednesday, February 5, 2021 at 12:00pm Eastern Time (ET) via email to bradley.hill@fda.hhs.gov.

10. Government Point of Contact: Bradley Hill, Contract Specialist, 301-796-8783, bradley.hill@fda.hhs.gov

11. Solicitation Number: FDA-SOL-21-1237651

12. Contract Award Dollar Amount: Estimated $102,200.00

13. Line Item Number: N/A

14. (Anticipated) Award Date: February 9, 2021

15. Contractor/Intended Source: SIMULATIONS PLUS, INC

16. Description: ADMET Software or Equal License Renewal. CTP will use the renewed

ADMET Predictor or equivalent software licenses to predict 140 properties including physico-chemical properties. Those properties are critical in vivo pharmacokinetic properties including sites of CYP metabolism, and various toxicities such as cardiotoxicity (hERG channel block), hepatotoxicity (elevation of liver damage markers), endocrine toxicity (estrogen and androgen receptor binding), reproductive/developmental toxicity, phospholipidosis, skin and respiratory sensitization, genotoxicity (Ames mutagenicity and chromosomal aberrations) and carcinogenicity (rat and mouse TD50).

CTP will use ADMET Predictor license renewals to create QSAR/QSPR models based on in-house data, and to perform advanced data mining, clustering, and matched molecular pair analysis. No NSN is assigned. Competition: SIMULATIONS PLUS, INC is the only authorized seller for the proprietary software manufacturer ADMET.

This solicitation is for ADMET or equal license renewals and support. FDA anticipates a Base period of 12 months, and four (4) option periods of 12 months each.

17. Place of Performance: Silver Spring, MD

18. Set-Aside Status: This requirement is not set-aside.

19. See the Attached Statement of Work for more information.