Attachment 2_Technical Evaluation Criteria.pdf

NIMH-20-004388 Attachment 2

Next Generation Sequencing (NGS) in Psychiatric Disorders

ATTACHMENT 2: TECHNICAL EVALUATION CRITERIA

The Government will award a contract or purchase order resulting from this requirement on the basis of best value, technical factors and price considered. Technical factors (Technical Approach, Ability to Perform Bioinformatics Analysis) together shall be considered more important than cost/price and past performance combined. The technical evaluation factors are detailed below:

1. Factor 1: Technical Approach (80%) The Offeror's proposal shall address each area of the statement of work requirements in sufficient detail to demonstrate a clear understanding of the technical proposal of how it meets the project requirements as set forth in the salient characteristics.

2. Factor 2: Ability to Perform Bioinformatics Analysis (20%) The Offer shall detail in its technical proposal the service providers ability to perform free bioinformatics analysis on the WES data. The original fastq files and the data analysis pipeline and the resulting VCF files will be given back to NIMH.

The Service provider will return the original fastq files generated for WGS and RNAseq to NIMH.

The turnaround time should be <60 days.

3. Factor 3: Past Performance (Not Scored) The offeror shall provide a list of two (2) past performance references completed during the past five (5) years, similar in size and scope to the requirements outlined in the Statement of Work.

Offerors shall include the following information for each contract identified:

• Name of Contracting Organization

• Contract Number

• Contract Type

• Total Contract Value

• Description of Requirement and Specific Responsibilities of the Offeror as they relate to this SOW

• Contract Period of Performance

4. Factor 4: Cost/Price (Not Scored)

Offeror(s) cost/price proposal will be evaluated for reasonableness. For a price to be considered reasonable, it must represent a price to the government that a prudent person would pay when consideration is given to prices in the market. Normally, price reasonableness is established

NIMH-20-004388 Attachment 2 through adequate price competition but may also be determined through cost and price analysis techniques as described in FAR 15.404. The Offeror shall submit firm fixed prices for all items listed in the SOW/PD (including option period(s) or optional lines, if applicable).

Technical proposals will be evaluated using a summary adjectival rating in accordance with the following scale:

Excellent The proposal has exceptional merit and reflects an excellent approach which will clearly result in the superior attainment of all requirements and objectives. The risk of unsuccessful performance is very low as the proposal provides a clear understanding of the requirements and demonstrates the offerors ability to meet the requirement. Risk Level: Very Low

Good The proposal demonstrates an approach which is expected to meet all requirements and objectives. This approach includes advantageous characteristics of substance, and few relatively minor disadvantages, which collectively can be expected to result in satisfactory performance. The risk of unsuccessful performance is low as the proposal contains alternative solutions which are considered feasible and practical. These solutions are further considered to reflect low risk in that they are clear and precise, supported, and demonstrate an understanding of the requirements. Risk Level: Low

Acceptable The proposal demonstrates an approach which is capable of meeting all requirements and objectives. The approach includes both advantageous and disadvantageous characteristics of substance, where the advantages are not outweighed by the disadvantages. Collectively, the advantages and disadvantages are likely to result in acceptable performance. The risk of unsuccessful performance is moderate, as the proposal solutions are generally feasible and practical. These solutions may also be considered to reflect moderate risk in that they may be somewhat clear and precise, partially supported, and/or demonstrate a general understanding of the requirements. Risk Level: Neutral

Marginal The proposal demonstrates an approach which may not be capable of meeting all requirements and objectives. The approach has disadvantages of substance and advantages, which if they exist, are outweighed by the disadvantages. Collectively, the advantages and disadvantages present a low or questionable likelihood of resulting in satisfactory performance. The risk of unsuccessful performance is high as the proposal contains solutions which may not be feasible and practical. These solutions may also be considered to reflect high risk in that they lack clarity and precision, are generally unsupported, and/or do not demonstrate a complete understanding of the requirements. Risk Level: High

NIMH-20-004388

Attachment 2

Unacceptable The proposal demonstrates an approach which, based on a very high risk, will very likely not be capable of meeting all requirements and objectives. This approach has several disadvantages of substance, and advantages which, if they exist, are outweighed by disadvantages.

Collectively, the advantages and disadvantages are unlikely to result in satisfactory performance. The risk of unsuccessful performance is very high as the proposal contains solutions which are not feasible and practical. The solutions may also be considered to reflect very high risk in that they lack any clarity or precision. Risk Level: Very High