RFP 75N95020R00018 Amendment 02.pdf

NSN 7540 - 01 - 152 – 8070 STANDARD FORM 30 (REV. 10-83)

PREVIOUS EDITION UNUSABLE Prescribed by GSA

FAR (48CFR) 53.243

OMB No. 0990-0115

AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT 1. CONTRACT ID CODE PAGE OF PAGES

1 2

2. AMENDMENT/MODIFICATION NO. 3. EFFECTIVE DATE 4. REQUISITION/PURCHASE REQ. NO. 5. PROJECT NO. (If applicable)

02 See Block 16C

6. ISSUED BY CODE JTL 7. ADMINISTERED BY (If other than Item 6) CODE

National Institutes of Health National Institute on Drug Abuse Office of Acquisitions c/o 3WFN MSC 6012 301 N Stonestreet Ave Bethesda, MD 20892

8. NAME AND ADDRESS OF CONTRACTOR (No., street, county, State and ZIP Code)

To All Potential Offerors

9A. AMENDMENT OF SOLICITATION NO.

75N95020R00018

9B. DATED (SEE ITEM 11)

February 25, 2020

10A. MODIFICATION OF CONTRACT/ORDER NO.

10B. DATED (SEE ITEM 13)

CODE FACILITY CODE

11. THIS ITEM ONLY APPLIES TO AMENDMENTS OF SOLICITATIONS

The above numbered solicitation is amended as set forth in Item 14. The hour and date specified for receipt of Offer is extended is not extended.

Offers must acknowledge receipt of this amendment prior to the hour and date specified in the solicitation or as amended, by one of the following methods:

(a) By completing Item 8 and 15, and returning 1 copies of the amendment; (b) acknowledging receipt of this amendment on each copy of the offer submitted; or (c) By separate letter or telegram which includes a reference to the solicitation and amendment numbers. FAILURE OF YOUR ACKNOWLEDG- MENT TO BE RECEIVED AT THE PLACE DESIGNATED FOR RECEIPT OF OFFERS PRIOR TO THE HOUR AND DATE SPECIFIED MAY RESULT IN REJECTION OF YOUR OFFER. If by virtue of this amendment you desire to change an offer already submitted, such change may be made by telegram or letter, provided each telegram or letter makes reference to the solicitation and this amendment, and is received prior to the opening hours and date specified.

12. ACCOUNTING AND APPROPRIATION DATA (If required)

13. THIS ITEM APPLIES ONLY TO MODIFICATIONS OF CONTRACTS/ORDERS,

IT MODIFIES THE CONTRACT/ORDER NO. AS DESCRIBED IN ITEM 14.

A. THIS CHANGE ORDER IS ISSUED PURSUANT TO: (Specify authority) THE CHANGES SET FORTH IN ITEM 14 ARE MADE IN THE CONTRACT/ORDER NO. IN ITEM 10A.

B. THE ABOVE NUMBERED CONTRACT/ORDER IS MODIFIED TO REFLECT THE ADMINISTRATIVE CHANGES (such as changes in paying office, appropriation data, etc.) SET FORTH IN ITEM 14, C. THIS SUPPLEMENTAL AGREEMENT IS ENTERED INTO PURSUANT TO AUTHORITY OF:

D. OTHER (Specify type of modification and authority)

E. IMPORTANT: Contractor is not, is required to sign this document and return copies to the issuing office.

14. DESCRIPTION OF AMENDMENT/MODIFICATION (Organized by UCF section headings, including solicitation/contract subject matter where feasible.)

PURPOSE: To revise and update Attachment 19 – Schedule of Contract Pricing (Dated May 7, 2020), please note specific revisions to line no. 15 in contract year 4 and 5. This amendment shall also extend the solicitation due date to May 13, 2020.

PROPOSAL DUE DATE: 3:00 p.m. (Eastern) on May 13, 2020 (CHANGED)

Note: The offeror should acknowledge on the cover page or first page of its business and technical proposals receipt of the RFP and this Amendment.

ALL OTHER TERMS AND CONDITIONS REMAIN UNCHANGED

Except as provided herein, all terms and conditions of the document referenced in Item 9A or 10A, as heretofore changed, remains unchanged and in full force and effect.

15A. NAME AND TITLE OF SIGNER (Type or print) 16A. NAME AND TITLE OF CONTRACTING OFFICER (Type or print)

Andrew R. Hotaling, Contracting Officer, NIDA Section

15B. CONTRACTOR/OFFEROR 15C. DATE SIGNED 16B. UNITED STATES OF AMERICA 16C. DATE SIGNED

(Signature of person authorized to sign)

BY

(Signature of Contracting Officer) 05/07/2020

Estimated Period of Performance: Sep 2020 - Sep 2025

Item No. Description of Service Inflation Price Per Unit ABCD Est. Annual

Volume Annual Price Price Per Unit ABCD Est. Annual

Volume Annual Price Price Per Unit ABCD Est. Annual

Volume Annual Price Price Per Unit ABCD Est. annual volume HBCD Est. annual volume ABCD Annual

Price HBCD Annual

Price Price Per Unit ABCD Est. annual volume HBCD Est. annual volume ABCD Annual

Price HBCD Annual

Price Price Per Unit ABCD Est. annual volume HBCD Est. annual volume ABCD Annual Price HBCD Annual Price

Receive Biospecimen Shipment (e.g. saliva, blood, serum, urine, hair, breastmilk, placenta, cord blood, teeth, stool)* -$ 1,067 -$ -$ 7,133 -$ -$ 9,000 -$ -$ 8,000 31,500 -$ -$ -$ 4,000 46,500 -$ -$ -$ 3,000 30,000 $ - $ -

2 DNA Extraction (whole blood, saliva, or other) -$ 1,067 -$ -$ 7,133 -$ -$ 9,000 -$ -$ 8,000 7,000 -$ -$ -$ 4,000 11,500 -$ -$ -$ 3,000 15,000 $ - $ - 3 DNA Extraction from Buffy Coat -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ $ - $ - 4 RNA Extraction -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ $ - $ - 5 Plasma Isolation and Aliquoting # -$ 900 -$ -$ 2,500 -$ -$ 4,000 -$ -$ 3,000 7,000 -$ -$ -$ 4,000 11,500 -$ -$ -$ 3,000 15,000 $ - $ - 6 Aliquoting services -$ 900 -$ -$ 2,500 -$ -$ 4,000 -$ -$ 3,000 21,000 -$ -$ -$ 4,000 31,000 -$ -$ -$ 3,000 15,000 $ - $ -

Metabolic Assays (i.e. Total Cholesterol, HDL, ferritin and HbA1C) # -$ 900 -$ -$ 2,500 -$ -$ 4,000 -$ -$ 3,000 -$ -$ -$ 4,000 -$ -$ -$ 3,000 $ - $ -

8 Cryopreserve PBMCs -$ -$ -$ -$ -$ -$ -$ 7,000 -$ -$ -$ 11,500 -$ -$ -$ 15,000 $ - $ - 9 Whole Genome Amplification -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ $ - $ -

10 Whole Genome Amplification Blood Spot Cards -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ $ - $ - 11 Whole Genome Amplification Serum -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ $ - $ -

Biospecimen Distribution (e.g. DNA, RNA, urine, feces, hair, teeth, breastmilk, etc.) -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ $ - $ -

Biospecimen Shipment (e.g. DNA, RNA, urine, feces, hair, teeth, breastmilk, etc.) -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ $ - $ -

Storage - Mechanical/per tube/year - room temperature (e.g. hair, teeth) -$ -$ -$ -$ -$ -$ -$ 3,500 -$ -$ -$ 7,500 -$ -$ -$ $ - $ -

Storage - Mechanical/per tube/year - frozen (e.g. DNA WB, Plasma, saliva, urine, feces) -$ 100,000 -$ -$ 60,000 -$ -$ 233,000 -$ -$ 289,000 255,500 -$ -$ -$ 357,000 607,000 -$ -$ -$ 408,000 862,000 $ - $ -

16 Storage - LN2/per ampule/year - Cryopreserved PBMC -$ -$ -$ -$ -$ -$ -$ 7,000 -$ -$ -$ 18,500 -$ -$ -$ 33,500 $ - $ - 17 Microarray - Exome Array -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ $ - $ - 18 Illumina Omni Microarray -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ $ - $ -

Microarray and Genotyping - processing, licensing, and data management for Smokescreen** -$ -$ -$ 4,000 -$ -$ 4,000 -$ -$ 5,000 -$ -$ -$ -$ -$ -$ $ - $ -

Microarray - SmokeScreen (chip / array)**** -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ $ - $ -

Genotyping - processing, licensing, and data management for Smokescreen**** -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ $ - $ -

22 RNA Sequencing -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ $ - $ - 23 Whole Genome Sequencing 30x -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ $ - $ - 24 Whole Genome Sequencing 50x -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ $ - $ - 25 Genomic Data Analysis -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ $ - $ - 26 cDNA Synthesis and Storage -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ $ - $ - 27 RNA/cDNA archival -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ -$ $ - $ - 28 Study Travel and Training*** -$ -$ -$ 3 -$ -$ 3 -$ -$ 3 3 -$ -$ -$ 3 3 -$ -$ -$ 3 3 $ - $ - 29 Administrative, IT and Database Work (Monthly Charge) -$ 2 -$ -$ 10 -$ -$ 12 -$ -$ 6 6 -$ -$ -$ 6 6 -$ -$ -$ 6 6 $ - $ -

Subtotal Per Study -$ -$ -$ -$ -$ -$ -$ -$ $ - Total Price -$ -$ -$

* Receiving shipment includes price of collection materials and shipping, and costs associated with accessioning ABCD Total HBCD Total

** These prices are available with minimum order of 10,000 microarrays for ultimate genotyping over the life of the contract. $ - $ - *** covers the travel cost for one contractor personnel to travel to domestic training site to train Pis, site coordinators and RAs. Total Contract Ceiling $ -

# covered by NHLBI for ABCD

Sample Task Order 5 - FY24 (Sept 2023 - Sept 2024) Contract Year 5

Sample Task Order 6 - FY25 (Sept 2024 - Sept 2025)

Estimated Volume Task Order Worksheet

Sample Task Order 1 - FY20 (Sept 2020-Oct 2020) Sample Task Order 3 - FY22 (Sept 2021 - Sept 2022)Sample Task Order 2 - FY21 (Nov 2020-Sept 2021) Contract Year 1 Contract Year 2 Contract Year 3 Contract Year 4

Sample Task Order 4 - FY23 (Sept 2022 - Sept 2023)

RFP Number : 75N95020R00018 Attachment 19 - Schedule of Contract Prices

May 7, 2020