Project Grant X3832704010

This Project Grant award, funded by the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program, supports research investigating the effects of ultraviolet radiation (UVR) exposure on chromatin structure and gene expression in melanocytes, which are the origin of cutaneous malignant melanoma. The $156,250 award, granted to the University of Toledo Health Science Campus, aims to elucidate how the loss of the BRG1 chromatin remodeling...

This $431,750.00 federal Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113) supports a two-year study at the University of Louisville to assess the environmental and health impacts of an industrial accident in Calvert City, Kentucky. The study aims to establish air quality monitoring sites, conduct wastewater surveillance, and perform quarterly biological sampling to comprehensively evaluate exposure...

This $463,375 federal Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113) supports research at the H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc. in Tampa, Florida. The research aims to identify and characterize the role of melanin-carbonyl-DNA (MCD) and melanin-carbonyl-protein (MCP) adducts in the progression and treatment resistance of NRAS mutant melanoma. The key objectives are to...

The National Institute of Environmental Health Sciences (NIEHS) awarded a $558,380 Project Grant under the Environmental Health federal grant program (CFDA 93.113) to the Icahn School of Medicine at Mount Sinai (ISMMS) to develop the GEOSPACE Geospatial Knowledgebase for Exposomics. This four-year project, starting February 1, 2025, aims to create an integrated biomedical knowledgebase and geospatial data science ecosystem to facilitate robust exposomic studies. The key products include: A...

The National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health Federal Grant Program (CFDA 93.113), awarded a $113,168 project grant to the University of Kansas Medical Center Research Institute, Inc. (KUMCRI) to investigate how the protein XRCC1 facilitates the enzyme DNA polymerase beta (Pol β) in repairing oxidative DNA damage within chromatin. The goal is to establish the structural and mechanistic details of how XRCC1 aids Pol β in searching for,...

The National Institute of Environmental Health Sciences (NIEHS) awarded a $441,529 Project Grant under the Environmental Health (CFDA 93.113) federal grant program to the University of Georgia Research Foundation, Inc. (UGA Research Foundation) on November 15, 2024. The grant supports research to elucidate the role of epitranscriptomic mechanisms, specifically N6-methyladenosine (m6A) RNA modification, in regulating astrocyte activation and neuroimmune dysfunction induced by chronic exposure...

This Project Grant award of $147,486 from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health federal grant program (CFDA 93.113), supports research by Thomas Jefferson University (doing business as Sidney Kimmel Medical College) to investigate the impact of oxidative stress on centromere integrity. The key objectives are to: 1) Investigate the DNA damage response at the centromere and the contribution of DNA repair factors in maintaining centromere...

This federal Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) program, provides $459,353 to the University of Toledo to conduct research on the discovery and characterization of novel cyanotoxins produced during harmful cyanobacterial blooms. The key objectives are to: 1) optimize high-performance liquid chromatography (HPLC) with native fluorescence detection and mass spectrometry (MS/MS) for structural...

This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program provides $421,047 to the University of Toledo to study the interaction between genetic and environmental risk factors for autism and other neurodevelopmental disorders. The key objectives are to investigate how developmental exposure to the pyrethroid pesticide deltamethrin interacts with a genetic mutation in the SHANK3 gene, which is associated with...

The University of Arkansas for Medical Sciences (UAMS) was awarded a $749,901.00 Project Grant on February 24, 2025 from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health federal grant program (CFDA 93.113). The project, titled "Understanding the Origins of the Mutational Landscape in Cancer", aims to elucidate the origins of mutational landscapes in cancer by integrating cellular DNA adductomics, nanopore long-read sequencing, and...