Project Grant S10OD040199
- Federal Grant Award Summary The National Institutes of Health Office of the Director awarded $405,787 to the University of Pennsylvania under the Research Infrastructure Programs (CFDA 93.351) to acquire and install an Asymmetric Field Flow Fractionation-Multiangle Light Scattering (AF4-MALS) system. This integrated analytical platform will be housed within the Johnson Foundation Structural Biology and Biophysics Core and will provide label-free separation and characterization capabilities for...
- Federal Grant Award Summary The University of Pennsylvania received a $438,609 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective May 7, 2026, with a completion date of February 28, 2031. This award supports the Hammer Laboratory's research combining gene editing technology with traction force microscopy (TFM) to advance understanding of mechanotransduction in leukocyte motility....
- Federal Project Grant Award Summary The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded the University of Pennsylvania a $616,897 Project Grant on August 8, 2025, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The award, with a completion date of July 31, 2026, funds development of synthetic intracellular microcompartments designed to enhance immune cell function in immunotherapy applications....
- Federal Grant Award Summary The Pennsylvania State University received a $1.00 Project Grant award from the National Institutes of Health Office of the Director under the Research Infrastructure Programs (CFDA 93.351) on May 15, 2025, with a completion date of May 14, 2026. This award supports the acquisition of a LUMICKS C-Trap single-molecule system, an integrated optical trap instrument that combines dual optical tweezers, scanning confocal fluorescence microscopy, and microfluidics...
- Federal Project Grant Award Summary The University of Pennsylvania received $749,993.00 in Project Grant funding from the National Institutes of Health Office of the Director under the Research Infrastructure Programs (CFDA 93.351) to procure an Olympus FV4000-MPE multiphoton laser scanning microscope equipped with a Spectra-Physics tunable infrared Ti:Sapphire pulsed laser. The award, dated July 15, 2025, with a completion date of July 14, 2026, establishes the first multiphoton intravital...
- Federal Grant Award Summary The University of Pennsylvania received a $446,875 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective April 6, 2026, with a completion date of December 31, 2030. This five-year research initiative focuses on elucidating the mechanisms and roles of RNA editing and sensing in immune regulation. The project aims to advance understanding of how...
- Federal Grant Award Summary The University of Pennsylvania received a $703,071 Project Grant award from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395), effective April 10, 2026, through March 31, 2031. This research initiative investigates the determinants of long-term chimeric antigen receptor T cell (CAR-T) persistence in patients with previously untreatable blood cancers. The project delivers fundamental research aimed at understanding why some...
- Federal Grant Award Summary The University of Pennsylvania received a $406,250 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective March 1, 2026 through December 31, 2030. This award supports the development of correlated latent factor models and advanced statistical methodologies for analyzing complex multimodal biomedical study designs. The research addresses a critical gap in current...
- Federal Grant Award Summary The University of Pennsylvania received a $406,250 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective August 1, 2025, through May 31, 2030. The award supports the development of novel hydration-centric molecular simulation techniques designed to advance computational methods for predicting and modulating protein interactions. The research deliverables...
- Federal Grant Award Summary The University of Pennsylvania received a $625,756 Project Grant award from the National Cancer Institute under the Cancer Detection and Diagnosis Research Program (CFDA 93.394), effective August 12, 2025 through July 31, 2028. This award supports development of BDEVS (Bead-based Digital Single Molecule-Single Extracellular Vesicle Sorting), a high-throughput microfluidic platform designed to advance early cancer detection through ultra-sensitive profiling of...
The University of Pennsylvania received a $573,005 Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Research Infrastructure Programs (CFDA 93.351) to acquire a LUMICKS AVIDION Cell Avidity Analyzer. The award, effective May 15, 2026 through May 14, 2027, funds the purchase and installation of this high-throughput scientific instrumentation platform designed to quantitatively measure cell-cell interaction avidity—a critical parameter for evaluating the efficacy of adoptive cellular immunotherapies, particularly Chimeric Antigen Receptor (CAR) T-cell therapies. The AVIDION system integrates centrifugal force-based technology, multicolor fluorescence imaging, automated liquid handling, and robotic cartridge management to enable simultaneous, high-throughput quantification of avidity across hundreds of experimental conditions, addressing significant measurement bottlenecks in existing institutional capabilities. The acquired instrument will serve multiple research projects across major and minor users at the institution, including systematic CRISPR-based screening of adhesion and costimulatory molecules influencing immune synapse formation; high-throughput quantification of anti-CD79 CAR T-cell avidity for lymphoma models; development of peptide-centric CAR-T cells targeting neoantigens in solid tumors; identification of resistance mechanisms in B-cell maturation antigen (BCMA)-targeted immunotherapies for multiple myeloma; and characterization of T-cell avidity impairments in lipid-rich tumor microenvironments. This shared research resource will accelerate discovery and clinical translation of engineered immune cell therapeutics across the University of Pennsylvania's cancer and immunotherapy research portfolio.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $573.0k | 5/7/26 |