Project Grant S10OD038157

Award Date 8/1/25
Completion Date 7/1/26
Dollars Obligated $1
Funding Federal Agency
Office of the Director
Federal Grant Program
93.351
Assistance Type
Project Grant
Place of Performance
Detroit, MI 48201, USA
Similar Awards
This Project Grant award of $1,980,309 from the National Institutes of Health (NIH) Office of Research Infrastructure Programs (ORIP) under CFDA 93.351 will fund the acquisition of an Orbitrap Astral mass spectrometer system for the Keck MS & Proteomics Resource at Yale University. The advanced instrument will enable rapid, high-resolution protein identification and quantification, supporting a wide range of proteomics research projects across Yale and external investigators. Key expected...
The National Institutes of Health (NIH) awarded a $1,352,820 Project Grant under the Research Infrastructure Programs (CFDA 93.351) to the Massachusetts General Hospital (MGH) to acquire a novel high-throughput and high-sensitivity mass spectrometer called the Orbitrap Astral. This state-of-the-art instrument will be used to conduct proteomic research focused on cancer and Alzheimer's disease at MGH. The Orbitrap Astral's unprecedented speed and sensitivity are expected to enable new...
This Project Grant award from the National Institutes of Health (NIH) Office of Research Infrastructure Programs (CFDA 93.351 - Research Infrastructure Programs) provides $1,658,828 to the Medical University of South Carolina (MUSC) to acquire a Thermo Scientific Orbitrap Astral Mass Spectrometer. This state-of-the-art mass spectrometry instrument will support NIH-funded research across multiple disease areas, including cancer, immunotherapy, cardiovascular disease, liver and digestive...
This Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) provides $150,000 to the Georgia Tech Research Corporation to purchase a Bruker timsTOF HT mass spectrometer and accompanying systems to upgrade the proteomics capabilities of the Georgia Tech Systems Mass Spectrometry Core Facility. The new state-of-the-art mass spectrometer will enable enhanced sensitivity, specificity, selectivity, dynamic range, and throughput to support proteomics research for 15...
The National Science Foundation Office of Integrative Activities awarded a $1,179,143 Project Grant to the University of New Hampshire (UNH) to acquire an Orbitrap Eclipse Tribrid mass spectrometer. This equipment will (i) dramatically improve UNH's mass spectrometry capabilities to expedite diverse research projects, (ii) facilitate hands-on training and inquiry-based learning on modern instrumentation, and (iii) establish a regional high-resolution mass spectrometry facility. The funding...
This $949,116 Project Grant awarded by the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351) will fund the acquisition of a Thermo Fisher Scientific Orbitrap IQ-X mass spectrometer system with a Vanquish Flex UHPLC system at the University of South Florida (USF). This cutting-edge analytical instrumentation will establish a unique omics capability at USF to support detailed, high-resolution structural analysis of low-level small molecules in complex...
This Project Grant award from the National Institutes of Health (NIH) Office of Research Infrastructure Programs (CFDA 93.351) provides $1,089,778 to The Regents of the University of Colorado (CU-Boulder) to purchase a high-resolution liquid chromatography-mass spectrometry system. The new instrument, consisting of a Waters Select Series Cyclic IMS QTOF mass spectrometer, ACQUITY PREMIER UPLC, and ACQUITY HDX Manager UPLC, will support small molecule, biomolecule, and post-translational...
This Project Grant award of $348,724 from the National Institutes of Health (NIH) Office of Research Infrastructure Programs (CFDA 93.351) will support the acquisition of an Agilent 6546 LC-QTOF mass spectrometer at Auburn University. This state-of-the-art instrumentation will enable high-resolution analysis of small molecules and biomolecules, replacing an outdated 15-year-old mass spectrometer and dramatically enhancing research capabilities across multiple disciplines including chemistry,...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $738,090 to the University of California, Irvine (UCI) to purchase a refurbished Orbitrap Eclipse Tribrid mass spectrometer. The new instrument will enable a major user group at UCI to conduct enhanced quantitative protein-based mass spectrometry experiments in support of multiple NIH-funded research programs. Key applications include...
The National Institutes of Health Office of the Director awarded Stanford University $3.8 million under the Research Infrastructure Programs grant program (CFDA 93.351) to acquire a new Orbitrap Tribrid mass spectrometry platform. For over 20 years, Stanford University Mass Spectrometry has served as the campus-wide shared proteomics resource, housing and maintaining mass spectrometry instruments to support numerous NIH-funded biomedical research projects spanning human development, degenerative...

ORBITRAP ASTRAL FOR WAYNE STATE PROTEOMICS - PROJECT SUMMARY/ABSTRACT THE GOAL OF THIS PROPOSAL IS TO BRING A THERMO FISHER SCIENTIFIC ORBITRAP ASTRAL MASS SPECTROMETER WITH A HIGH-FIELD ASYMMETRIC WAVEFORM ION MOBILITY SPECTROMETRY (FAIMS PRO DUO) DEVISE, AN ARDIA INSTRUMENT CONTROL AND DATA MANAGEMENT SYSTEM PLUS A NANO-LC TO THE PROTEOMICS CORE AT WAYNE STATE UNIVERSITY. THE PROTEOMICS CORE SUPPORTS AN EXTENSIVE USER BASE INCLUDING 7 MAJOR USERS AND 19 MINOR USERS WHO HAVE CONTRIBUTED TO THE PROPOSAL AND WHO HAVE NIH-FUNDED PROJECTS THAT WILL BE ADVANCED BY HAVING ACCESS TO THE ORBITRAP ASTRAL. THE PROTEOMICS CORE AT WAYNE STATE ALSO SUPPORTS THE KARMANOS CANCER INSTITUTE AND THE P30 FUNDED CANCER CENTER AS WELL AS THE NIEHS FUNDED CURES P30 CENTER AND CLEAR P42 SUPERFUND CENTER. THIS ORBITRAP ASTRAL HAS UNIQUE CAPABILITIES FOR DEEP PROFILING OF COMPLEX PROTEOMES USING DATA INDEPENDENT ANALYSIS (DIA) ACQUISITION. ADVANCES IN THE ORBI ASTRAL THAT MAKE IT UNIQUE FOR DIA ARE THE 200 HZ SCAN SPEED WITH 80,000 RESOLUTION AND SUPERIOR SENSITIVITY. THESE FEATURES ALLOW THE ASTRAL TO ACQUIRE DIA DATA USING 2 DA WINDOWS, SOMETHING NO OTHER MS SYSTEM CAN ACHIEVE. THE NEW MASS ANALYZER IN THE ORBITRAP ASTRAL MAKE IT AN EXCEPTIONAL INSTRUMENT FOR DIA PROTEOMICS. COMBINED WITH THE EXPERIENCED MASS SPECTROMETRISTS IN THE CORE, THE ORBITRAP ASTRAL WILL BE A MAJOR ASSET TO RESEARCH PROGRAMS OF NIH-FUNDED INVESTIGATORS AT WSU AND IN THE SE MICHIGAN REGION. AS INVESTIGATOR NEEDS HAVE EVOLVED THEY HAVE DEVELOPED AN INCREASED NEED FOR HIGHER RESOLUTION, GREATER SENSITIVITY AND HIGHER MASS ACCURACY PROTEOMIC MASS SPECTROMETRY. THE ORBITRAP ASTRAL IS DESIGNED TO ADDRESS TODAYS NEEDS IN PROTEOMIC ANALYSIS. THE INSTRUMENT EXCELS AT DEEP SEQUENCING AND QUANTITATIVE PROTEOMICS AS WELL AS ACCURATE CHARACTERIZATION OF POST TRANSLATIONAL MODIFICATIONS. THE CURRENT MASS SPECTROMETERS IN THE CORE LACK FAST DUTY CYCLES AND THE ADVANCED ION OPTICS THAT MAKE DETECTION OF LOW ABUNDANCE SPECIES ROUTINE ON THE ASTRAL. THE ABILITY TO UNAMBIGUOUSLY LOCALIZE POST TRANSLATIONAL MODIFICATIONS (PTM) IN PEPTIDES IS A CRITICAL FEATURE IN ANY PROTEOMIC MS SYSTEM AND THE ASTRAL IS OUTSTANDING IN THIS DUE TO THE HIGH DEGREE OF COVERAGE WITHIN THE IDENTIFIED PROTEINS. WAYNE STATE UNIVERSITY IS STRONGLY COMMITTED TO THIS PROPOSAL AS EVIDENCED BY A COMBINED $350,000 IN NEW SUPPORT FOR THE INSTRUMENTS MANAGEMENT, OPERATION, MAINTENANCE, INFORMATICS AND USAGE. THE TECHNICAL EXPERTISE OF PROTEOMICS CORE PERSONNEL AS WELL AS THE PHYSICAL AND ADMINISTRATIVE INFRASTRUCTURES ARE ALL IN PLACE AND READY TO IMMEDIATELY PUT THIS NEW MASS SPECTROMETER TO WORK ON NIH-FUNDED BIOMEDICAL RESEARCH PROJECTS. THIS INSTRUMENT WILL PROVIDE TRANSFORMATIVE TECHNOLOGIES FOR ADVANCING DOZENS OF NIH- FUNDED, ONGOING PROJECTS, AS WELL AS CATALYZING NEW RESEARCH DIRECTIONS FOR INVESTIGATORS AT WAYNE STATE UNIVERSITY.

Posted 7/23/25, 12:00 AM