Project Grant RF1NS146594
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded Wake Forest University $533,623 on September 3, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research investigating mechanisms that protect neurons from glutamate excitotoxicity during metabolic stress. The research uses avian neurons, which naturally resist...
- The National Institute of Neurological Disorders and Stroke (NINDS), part of the Department of Health and Human Services National Institutes of Health, awarded The Medical University of South Carolina $100,228 on December 16, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research on complement-mediated mechanisms of injury and repair in germinal matrix hemorrhage, a leading neurological injury of prematurity....
- The National Institute of Neurological Disorders and Stroke awarded the University of California, Los Angeles $639,095 on August 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to support research on temporal control of neurogenesis termination in developing mammalian brains. The research investigates the molecular mechanisms by which neural stem cells, or radial glia, cease generating neurons shortly after birth—a process...
- The National Institute of Neurological Disorders and Stroke awarded The Rockefeller University $630,609 on July 14, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate glial cell roles in preserving dendrite integrity following neuronal injury. The research explores how glial cells sense and respond to damage in neuronal dendritic structures and substructures, including dendritic spines and sensory neuron cilia. The...
- The National Institute of Neurological Disorders and Stroke (NINDS), part of the Department of Health and Human Services National Institutes of Health, awarded $671,988 to the Winifred Masterson Burke Medical Research Institute, Inc. on September 11, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The recipient will conduct research on cross-talk between sarmoptosis and ferroptosis in hemorrhagic stroke, specifically...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded The Regents of the University of California, San Francisco $128,139 on September 23, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research to develop a multi-modal transcriptomic atlas of normal and diseased cerebral vasculature, with focus on mural cell biology in brain arteriovenous malformations (BAVMs). The research consists of two...
- The National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health, awarded Oregon Health & Science University $858,000 on September 24, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds in vivo investigations of astrocyte-oligodendrocyte interactions using molecular, genetic, cellular, and proteomic tools to define astrocyte-oligodendrocyte myelin interactions at the...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded Yale University $667,613 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research examining ferroptosis—iron-induced programmed cell death—in erythrocytes within intracerebral hemorrhage hematomas. The project investigates how heme induces...
- The National Institute of Neurological Disorders and Stroke awarded the University of Southern California $181,891 on January 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the RNA-regulatory activities of the RNA exosome during human motor neuron differentiation. The research examines how the RNA exosome, a post-transcriptional ribonuclease complex, regulates gene expression during stem cell differentiation...
- The National Institute of Neurological Disorders and Stroke awarded the University of Missouri System $329,234 on June 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to support research on synaptic function during metabolic stress. The research project, titled "Transforming Synapses to Operate During Extreme Metabolic Dysfunction," investigates how the brain maintains synaptic performance when energy delivery...
The National Institute of Neurological Disorders and Stroke awarded the University of Southern California $1.245 million on August 18, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate mechanisms of differential vulnerability in the central nervous system and their implications for translating preclinical findings to successful clinical trials. The research examines why neurons, glia (astrocytes and microglia), endothelial cells, and pericytes respond differently to ischemic injury and tolerate substrate deprivation on different time scales. The work focuses on the molecular and cellular mechanisms underlying this differential vulnerability, with emphasis on the role of the nuclear factor erythroid 2-related factor (NRF2) mediated oxidative stress response in astrocyte survival during cerebral ischemia. The investigation explores how oxidative injury activates multiple cell-death pathways including ferroptosis, necrosis, apoptosis, necroptosis, and parthanatos, and tests whether different cell types require cytoprotection at different times during ischemic events. Performance occurs in Los Angeles, California through July 31, 2029. The award is structured as a Project Grant, the standard assistance type for extramural research under NINDS.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.2m | 8/18/26 |