The Jackson Laboratory, Emory University, Columbia University, and Rush University Medical Center have been awarded a $5,949,022 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) from the National Institute of Neurological Disorders and Stroke. The grant aims to establish a "VCID Center Without Walls" to prioritize novel therapeutic targets for vascular contributions to cognitive impairment and dementia (VCID). The research will focus on understanding factors mediating cerebral amyloid angiopathy, including its interactions with tau pathology and APOE genotype, in order to develop treatments targeting cerebrovascular dysfunction in Alzheimer's disease and related dementias. The project will leverage human samples, multi-omic data, and novel mouse models to identify and validate vascular-specific targets. Sub-awardees including Rush University Medical Center, Emory University, and Columbia University will provide data, biospecimens, specialized analyses, and expertise to support the overall research goals.
Generated 3/4/25, 4:08 AM