This Project Grant award of $2,403,545 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders federal grant program (CFDA 93.853), supports research to examine the epigenetic mechanisms linking social determinants of health (SDOH) exposures to vascular cognitive impairment and dementia (VCID) after intracerebral hemorrhage (ICH) stroke. The research, titled REACH-EPIVCID, will identify epigenetic changes associated with SDOH-induced environmental differences, VCID, and blood pressure treatment resistance in a cohort of 700 ICH survivors. This will include genome-wide genotyping of 607 participants and formal mediation analyses to test causal pathways between SDOH, epigenetics, and adverse cognitive outcomes. The project is an extension of the ongoing REACH-ICH parent study and aims to yield insights into biologically modifiable targets for preventing VCID in populations disproportionately impacted by adverse SDOH. Sub-awards support quality control, data analysis, and coordination efforts by researchers at Mass General Brigham Inc. and Wake Forest University Health Sciences.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $2.4m | 8/5/24 |
Grant Number | Description | Subgrantee | Prime Award | Dollars Obligated (Click to sort descending) | Updated At (Click to sort ascending) |
|---|---|---|---|---|---|
131660S | Mass General Brigham Incorporated | Project Grant RF1NS139183 | $280.2k | 12/17/24 | |
131660S | Wake Forest University Health Sciences | Project Grant RF1NS139183 | $66.8k | 11/1/24 |