Project Grant RF1NS129022
Award Date
7/15/22
Completion Date
6/30/25
Dollars Obligated
$3.6M
Funding Federal Agency
National Institute on Aging
Awarding Federal Agency
National Institute of Neurological Disorders and Stroke
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Colorado, USA
Similar Awards
This federal Project Grant award of $2,398,590.00 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to investigate the role of brain microvascular dysfunction in cognitive impairment and dementia. The multidisciplinary research team at the University of Colorado-Denver will use a variety of experimental approaches, including animal models, native...
This Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) provides $10,847,672 in funding to the J. David Gladstone Institutes in San Francisco to conduct research on vascular-immune mechanisms underlying cerebral amyloid angiopathy (CAA) and Alzheimer's disease pathology. The research aims to elucidate the cellular and molecular processes that regulate the balance between vascular and parenchymal amyloid-beta accumulation, with a focus on the role of...
The National Institute on Aging awarded a $4.6 million Project Grant to Cornell University under the Aging Research program (CFDA 93.866) to develop new imaging techniques for measuring microvascular blood flow in Alzheimer's disease and related dementia models. The award will support the design of an adaptive excitation source for 2-photon and 3-photon fluorescence microscopy to simultaneously measure blood flow speeds in approximately 300 cortical or 50 deep white matter microvessels. This...
This $4.49 million project grant from the National Institutes of Health's National Institute on Aging will fund research at The Washington University to investigate the relationship between amyloid plaque deposition, cellular metabolic dysfunction, and functional brain organization in Alzheimer's disease (AD) mice models. Over three years, the researchers will use multi-photon fluorescence lifetime imaging microscopy, multi-parametric photoacoustic microscopy, and wide-field optical imaging to...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will provide $631,577.00 to the University of Miami to conduct research on the role of neutrophils in vascular inflammation associated with vascular contributions to cognitive impairment and dementia (VCID) and mixed Alzheimer's disease. The key objectives are to: 1) use longitudinal in...
This federal Project Grant award of $2,342,415 from the National Institute on Aging's Aging Research program (CFDA 93.866) funds research to investigate the cellular and molecular mechanisms underlying adverse cerebrovascular responses, such as amyloid imaging-related abnormalities (ARIA-E and ARIA-H), that can occur during passive anti-amyloid beta (Aβ) immunotherapy treatments for Alzheimer's disease. The key objectives are to: 1) examine the temporal sequence and vascular aging components...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $6,226,692.00 to support research on the role of neuronal hyperexcitability and proteostasis in Alzheimer's disease (AD). The project aims to investigate how modifications in brain activity, specifically in the locus coeruleus (LC) and hippocampus (HPC), can lead to the development and progression of AD pathology. The key research objectives are to: Track early electrophysiological...
This $1,931,965 Project Grant awarded by the National Institute on Aging (CFDA 93.866 Aging Research program) will fund the development and validation of a novel, human induced pluripotent stem cell (iPSC)-based model that incorporates cerebral cortical neurons, glia, vascular endothelial cells, pericytes, and microglia. The goal is to create an advanced in vitro model with improved construct, face, and predictive validity for studying the cerebrovascular interactions relevant to Alzheimer's...
This $342,934.65 project grant from the Department of Health and Human Services National Institutes of Health National Institute on Aging, under the Aging Research program (CFDA 93.866), will fund research into acyl chain remodeling and regional lipid dysregulation in Alzheimer's disease. The Trustees of Columbia University in the City of New York, doing business as Health Sciences Division, will analyze lipid composition in brain regions susceptible to Alzheimer's disease, such as the...
This $1,955,041 Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), will fund research into the relationship between sleep, pericytes, and Alzheimer's disease pathology. The Medical University of South Carolina will investigate whether pericytes, cells that regulate cerebral blood flow and blood-brain barrier permeability, mediate the effects of sleep disruption on Alzheimer's disease progression. Specifically, the...