This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $2,415,243 to The Broad Institute, Inc. to develop a scalable, cloud-based framework for multi-modal mapping across single neuron omics, morphology, and electrophysiology. The framework aims to enable integrative, data-driven characterization of brain cell types, leveraging federated Brain Initiative resources and community engagement....
This $2,623,223 Project Grant awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will fund the development of CLOUDSLEAP, a cloud-based platform to enhance accessibility to deep learning-based motion capture technology for behavior quantification. The key products and services to be delivered through this 3-year grant include: Enabling annotation, visualization, and sharing of pose tracking datasets directly from the browser,...
The National Institute of Mental Health (NIMH) awarded a $2,515,724 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to the Regents of the University of Michigan to further develop NTracer2, a cloud-based platform for brain image visualization and neuron tracing. The project aims to establish NTracer2's SISF data framework as a scalable image data standard, continue developing the NTracer2 content delivery network and application server, and deploy the full-stack...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $769,352 to The Leland Stanford Junior University to develop an engineered bioprinting platform for studying neural migration in brain assembloids. The key objectives are to: 1) Improve the size and organizational reproducibility of brain organoids from distinct brain regions, 2) Use the bioprinting technology to precisely position...
This $2,220,017.04 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will support a large-scale, single-cell characterization of the molecular and cellular networks underlying mood regulation circuitry in major depressive disorder (MDD). The key products and services to be delivered include: 1) identifying transcriptomic changes associated with MDD at the single-cell level across 800 human postmortem brain...
The National Institute of Mental Health awarded a three-year Project Grant totaling $3,618,976 to the University of California, Los Angeles under the Mental Health Research Grants program (CFDA 93.242) to develop in situ single-cell multi-omic and morphological profiling methods for mammalian brains. Specifically, the university will work to design photonic-indexing sequencing strategies to spatially barcode tissue with single-cell resolution, integrating techniques such as PI-ATAC-seq and...
This Project Grant award from the National Institute of Mental Health (NIMH) under CFDA 93.242 Mental Health Research Grants provides $1,096,486.32 to New York University (NYU) to support a 3-year research project investigating the transcriptional basis of stereotyped neural architectures. The key objectives are to: Elucidate the genetic programs responsible for the formation and maintenance of neural architectures in the nervous systems of Caenorhabditis elegans and the rodent hippocampus. This...
The National Institute of Mental Health (NIMH) awarded a $147,656 Project Grant (CFDA 93.242 - Mental Health Research Grants) to The Washington University in St. Louis to support research on the evolutionary expansion of the human cerebral cortex. The research aims to generate more accurate maps of cortical expansion in humans compared to macaques, and analyze associated transcriptional changes at the cellular level. Key activities include leveraging state-of-the-art neuroimaging and single-cell...
This Project Grant award from the National Institutes of Health (NIH) Office of the Director, under the Trans-NIH Research Support program (CFDA 93.310), provides $1,271,280 to the Allen Institute in Seattle, Washington to develop two "exa-scale tissue readout methods" that will dramatically improve throughput for high-resolution, highly multiplexed imaging of large tissue volumes. The first platform aims to enable molecular-scale mapping of individual proteins across entire brains,...
This $2,286,510 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research to develop a computational framework for understanding neural circuit dynamics and their role in cognition. The award to New York University will fund the development of analytical models, called Oscillatory Recurrent Gated Neural Integrator Circuits (ORGANICS), to simulate neural mechanisms underlying attention, working memory,...