Project Grant RF1AG093281
- This $745,765 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the Icahn School of Medicine at Mount Sinai (ISMMS) in New York aims to investigate the effects of Alzheimer's disease (AD) risk genes and aging on human microglia activity and lipid metabolism. The key focus is on understanding how genetic variants associated with increased AD risk or longevity may impact microglia's ability to clear cholesterol/lipid-rich cellular debris, a critical...
- The Washington University in St. Louis, Office of Sponsored Research Services Division, received a $2,133,060 Project Grant award from the National Institute on Aging under the Aging Research program (CFDA 93.866). The grant will support research to investigate the sex-dependent effects of stress on the accumulation of amyloid-beta (Aβ) and tau proteins, which are hallmarks of Alzheimer's disease pathology. The study aims to elucidate the signaling pathways that mediate the differential...
- The Icahn School of Medicine at Mount Sinai received a $307,801 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research program) to develop and implement the Postbaccalaureate Alzheimer's Disease Development Initiative (PADDI), a two-year program to train postbaccalaureate students about Alzheimer's disease and related dementia research methodologies and the ethical conduct of research. The program aims to address a lack of ethnic and racial diversity among...
- This $999,975.63 federal Project Grant, awarded by the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420), supports research by the Icahn School of Medicine at Mount Sinai to investigate the molecular mechanisms behind the increased vulnerability of the APOE4 gene to Alzheimer's disease and identify potential new therapeutic targets. The award period runs from April 1, 2025, to March 31, 2028. The Icahn School of Medicine at Mount Sinai is a leading...
- This federal Project Grant award of $463,916.00 was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) to the Icahn School of Medicine at Mount Sinai. The funding will support a 2-year research project to identify a novel cytoplasmic activation platform for the caspase-2 enzyme, referred to as the "Ankosome", which may play a role in neuronal cell death in Alzheimer's disease. The project aims to elucidate the molecular...
- This $420,834 Project Grant was awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to the Icahn School of Medicine at Mount Sinai. The grant will be used to elucidate the neural mechanisms connecting the brain and heart during stress, focusing on two key communication pathways: bottom-up (nodose ganglion to nucleus of the solitary tract) and top-down (nucleus ambiguus to the heart). The research aims...
- This federal Project Grant award of $459,250.00 from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) is focused on investigating the impact of stress and resilience on the longitudinal trajectories of Alzheimer's disease (AD)-related brain pathology and cognitive function. The research aims to elucidate the mechanisms by which stress may predispose individuals to long-term cognitive changes and the development of AD. The awardee, The General Hospital...
- This federal Project Grant award of $145,566 from the National Institute on Aging (CFDA 93.866 - Aging Research) is supporting research at the Icahn School of Medicine at Mount Sinai to investigate how the brain accumulates and utilizes "cognitive maps" - internal neural representations that enable flexible behavior and memory recall. The research aims to provide insights into the neuronal coding deficits underlying cognitive decline, with the goal of informing therapeutic...
- The National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), awarded a Project Grant in the amount of $4,035,962.00 to the Icahn School of Medicine at Mount Sinai (ISMMS) on September 15, 2025. The grant is titled "Examining Unique Markers and Risk Factors for AD/ADRD in Foreign- and Native-Born Older Chinese Americans: A Study of Social Determinants of Health, Sleep Patterns, Neuroimaging, and Plasma Biomarkers." The project aims to...
- The National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), awarded a $245,434 project grant to Wake Forest University Health Sciences (WFUHS) to examine the associations between early and later-life stress on later-life cognition and plasma biomarkers of Alzheimer's disease and related dementias (ADRD). The study aims to investigate how stress experienced across the lifespan, as well as perceived psychological stress, may impact cognitive decline and...
The Icahn School of Medicine at Mount Sinai received a $3,548,990 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to investigate the influence of stress on the expression of neuropsychiatric symptoms (NPS) in Alzheimer's disease (AD) mouse models. The goal is to test the hypothesis that promoting stress resilience could prevent or delay the emergence of AD-associated NPS. The 4-year project, starting on Sep 1, 2025, will examine how stress susceptibility is linked to microglia activation in the prefrontal cortex and disrupts its neurophysiological properties. The research aims to elucidate the neurobiology and underlying mechanisms of NPS in AD, with the objective of developing interventions to enhance stress resilience and mitigate the development of these behavioral symptoms.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $3.5m | 8/26/25 |