Project Grant RF1AG090712
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,489,452.00 to the University of California, Irvine to investigate circuit vulnerability in the lateral and medial entorhinal cortices in Alzheimer's disease (AD) tauopathy models. The research aims to identify specific neuron subtypes in the entorhinal cortex that are vulnerable to the tau protein pathology in AD, and how this relates to impaired memory function. The project is...
- The National Institute on Aging (NIA) awarded a $773,816 project grant under the Aging Research federal grant program (CFDA 93.866) to the University of California, Irvine (UCI) to conduct comparative studies on new tau-directed Alzheimer's disease (AD) and AD-related dementias (ADRD) mouse models and human AD/ADRD brain tissues. The project aims to generate single-cell spatial proteo-transcriptomics maps to molecularly characterize aberrant RNA splicing and abnormal protein products in specific...
- The federal Project Grant award from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), provides $426,674 to the University of North Carolina at Chapel Hill to investigate the "Implications of Long-Range Mossy Cell Signaling and Connectivity in Alzheimer's Disease (AD)". The 2-year project, starting on September 1, 2025, aims to identify changes in the activity of glutamatergic mossy cells in the dentate gyrus of the hippocampus and their impact on...
- The National Institute on Aging (NIA) awarded a $1,459,072 project grant to the J. David Gladstone Institutes under the Aging Research Federal Grant Program (CFDA 93.866) to monitor and manipulate inhibitory interneuron cell populations in mouse models of Alzheimer's disease. The 2-year project aims to use dual cell-type-specific enhancer-associated adeno-associated viruses (enhancer-AAVs) to independently monitor and control parvalbumin (PVALB) and somatostatin (SST) inhibitory interneurons...
- This federal Project Grant award of $2,316,710 from the National Institute on Aging (CFDA 93.866 Aging Research) aims to develop magnetogenetic techniques for manipulating the activity of specific brain cell types implicated in the onset and progression of Alzheimer's disease (AD). The research will focus on using a magnetogenetic tool called FERIC (Ferritin Iron Redistribution to Ion Channels) in combination with enhancer AAV vectors to non-invasively control the activity of AD-vulnerable...
- This $749,108 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to understand how memory failures lead to decision failures across the lifespan. The research will use computational and neurobiological approaches to measure the influence of different types of memory - item, context, and statistical learning - on decision-making choices. The project will examine these questions in cognitively normal older adults through behavioral tasks,...
- This federal Project Grant award of $307,000.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to conduct a single, highly powered study to identify memory processes that are most sensitive to the asymptomatic, preclinical stage of Alzheimer's disease (AD) pathology. The study combines a continuous report item-location associative memory task with advanced behavioral and neural modeling to estimate subtle changes in memory precision that may differentiate healthy...
- The University of California Irvine will receive $4,522,968 over three years from the National Institutes of Health National Institute on Aging under the Aging Research grant program (CFDA 93.866) to investigate the temporal, spatial and cellular dynamics of amyloid plaque deposition in Alzheimer's disease. The research will utilize cutting-edge biorthogonal non-canonical amino acid tagging technology and cell-specific Cre driver mouse lines to label the proteomes of specific cell types and...
- This federal Project Grant award of $839,933 from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research to investigate the role of N6-methyladenosine (m6A) RNA modifications in microglial dysfunction and Alzheimer's disease (AD) pathogenesis. The project aims to systematically map m6A modification landscapes in microglia isolated from human brain tissue and human induced pluripotent stem cell-derived microglial models. The researchers will also use CRISPR-based...
- This federal Project Grant award of $372,690, provided by the National Institute on Aging (CFDA 93.866 Aging Research), aims to comprehensively understand the heterogeneous causal pathophysiology of Alzheimer's disease (AD). The key objectives are to: (1) develop new statistical methods for uncovering heterogeneous causal relationships among amyloid-beta, tau accumulation, and cognition across diverse AD datasets; (2) apply these methods to reveal optimal treatment windows and target populations...
This federal Project Grant award of $3,221,450.00 from the National Institute on Aging (CFDA 93.866 Aging Research) supports research to define how neuronal hyperexcitability in the retrosplenial cortex (RSC) contributes to the development of Alzheimer's disease (AD)-related behavioral deficits in mouse models. The research aims to determine the effect of inhibiting RSC layer 5 cells on spatial memory and navigation, as well as when hyperexcitability emerges in these cells across different AD mouse models. The University of California, Irvine is the awardee and will conduct this work over the project period of September 15, 2025 through August 31, 2029. The findings may help identify early drivers of AD pathogenesis and inform the development of new AD therapeutics.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $3.2m | 9/10/25 |