This $2,151,878 federal Project Grant award, funded by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), supports research at the University of North Carolina at Chapel Hill (UNC-CH) and its subrecipient, the University of Pennsylvania, to map the causal genetic-imaging-clinical pathway for Alzheimer's disease (AD).
The key products and services to be delivered through this 3-year project include:
-
Developing robust functional connectome analysis and causal genetic-imaging-clinical frameworks to uncover the genetic architecture of brain function and discover causal pathways from genes to AD progression and clinical measures.
-
Integrating multi-type data, including genetics, neuroimaging, health records, and cognitive information, from large-scale biomedical studies like the UK Biobank, ADNI, and HCP to provide insights into AD pathology and healthy aging.
-
Disseminating analytical tools and research findings through companion software and a knowledge portal to benefit the broader scientific community studying neuropsychiatric, neurodegenerative, and substance use disorders.
The University of Pennsylvania research team will provide data management, analysis, and modeling support for the imaging genetics components of the project.
Generated 8/13/24, 3:54 AM