Project Grant RC2MH090877

This $455,824.20 Project Grant from the National Center for Advancing Translational Sciences will fund research to identify direct interactions between understudied G protein-coupled receptors (GPCRs) and protein kinase A (PKA) isoforms. The University of Utah will utilize the National Institutes of Health's existing Prestwick Chemical Library and NanoBRETT kinase assay platforms to develop a high-throughput screening assay for GPCR-PKA interactions. This assay will then be applied to...

This Project Grant from the National Institutes of Health's National Cancer Institute totaling $668,151 will support the development of highly multiplexed live-cell G protein-coupled receptor (GPCR) arrays for glioma drug discovery. Spectragenetics, Inc. will deploy an automated multiplexed live-cell assay to detect and quantify agonist and inverse-agonist activities against 55 GPCRs known to be upregulated or downregulated in human gliomas. The assay will be used to screen 48 established...

Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded $377,123 to The Research Foundation For The State University Of New York (SUNY at Binghamton) under the Biomedical Research and Research Training program (CFDA 93.859) on September 1, 2025, for a project period extending through June 30, 2030. This Project Grant supports fundamental biomedical research focused on determining the structural and mechanistic bases for ligand specificity of...

This federal Project Grant award of $349,566 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of a Spotting-Free Nano-Oscillator Array (SFNOA) technology for high-throughput, label-free quantification of ligand binding kinetics to transmembrane proteins in their native states. The key products and services delivered through this award include: Integration of innovative technologies...

Federal Grant Award Summary Baylor College of Medicine received a $480,000 Project Grant from the National Institute on Drug Abuse under the Drug Use and Addiction Research Programs (CFDA 93.279) awarded September 1, 2025, with completion targeted for May 31, 2030. The award supports development of innovative chemical biology tools and computational methods to advance drug discovery targeting G protein-coupled receptors (GPCRs), particularly those implicated in opioid abuse and the broader...

Federal Project Grant Award Summary Epigen Biosciences Inc. received a $699,998 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 12, 2025, with completion targeted for August 31, 2026. The award funds research and development activities for novel methods of nicotinic receptor modulation to address post-operative and chronic pain management. Specifically, Epigen is...

This $1,511,970 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports the development of selective GPR34 antagonists for the treatment of neuropathic pain. The award aims to identify CNS-active GPR34 hits that can be further developed into novel GPR34 antagonists as potential drug candidates for neuropathic pain. Key products and services include: 1) Synthesis and testing of novel...

This Project Grant from the National Institutes of Health National Institute on Drug Abuse, under the Drug Abuse and Addiction Research Programs (CFDA 93.279), provides $640,000 to Olfa Thera, Inc. to develop new therapeutics targeting the OLFR78/OR51E2 receptor pathway in the carotid body. The goal is to identify OLFR78/OR51E2 agonists that can strongly stimulate carotid body activity and ventilation to reverse opioid-induced respiratory depression, without the side effects of existing...

The National Institute of Neurological Disorders and Stroke (NINDS) awarded Emory University a $430,375 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to study disease-associated mutations and ligand activation of the adhesion G protein-coupled receptor ADGRB2. The key objectives are to: Investigate newly identified patient mutations in the ADGRB2 gene that are associated with spastic paraparesis and other neurological symptoms,...

Federal Project Grant Award Summary Saint Louis University received a $833,250 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded June 5, 2025, with completion targeted for March 31, 2030. The project, "Optical Control of G Protein-Coupled Receptor Function," will deliver innovative molecular tools and research findings to advance understanding and manipulation of G...