Project Grant R61NS145988
- The National Institute of Neurological Disorders and Stroke awarded The Washington University $427,625 under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) on September 1, 2026, for research on imaging fibrosis formation in peripheral nerve injury. The award funds a two-year proof-of-principle study addressing fibrosis complications in surgical repair of severe peripheral nerve injuries. Research Aim 1 focuses on real-time visualization...
- The National Institute of Neurological Disorders and Stroke awarded The Washington University $617,439 on July 21, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to examine how lesion location and extent affect post-stroke neuroplasticity and recovery mechanisms. The project will use rat stroke models with varying lesion sizes and locations—systematically manipulating damage to the corticospinal tract and lesions in the cortex...
- The National Institute of Neurological Disorders and Stroke awarded The Washington University $618,077 on June 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop next-generation tools for human cortical cartography. The award funds generation of a multi-modal atlas of human cortical areas with improved accuracy beyond the 2016 version, characterization of individual variability and subareal organization within cortical...
- The National Institute of Neurological Disorders and Stroke awarded The Washington University $245,874 on July 2, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop therapies that reprogram astrocytes to promote neural repair following spinal cord injury. The research defines pro-regenerative glial cell reactivity in zebrafish, performs an in vivo CRISPR screen to identify transcription regulators of that reactivity,...
- The National Institute of Neurological Disorders and Stroke awarded The Washington University $618,108 on June 18, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to conduct research on neuroinflammation in cerebral small vessel disease, a leading vascular contributor to cognitive impairment and dementia. The recipient will evaluate the relationship between 11C-CS1P1 PET uptake—a novel positron emission tomography radiotracer...
- The National Institute of Neurological Disorders and Stroke awarded Washington University $231,264 on April 8, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to identify and validate cerebroprotective drug targets in humans with acute ischemic stroke caused by large vessel occlusion. The research collects paired periprocedural arterial blood samples during endovascular thrombectomy procedures at Barnes-Jewish Hospital/Washington...
- The National Institute of Neurological Disorders and Stroke awarded Emory University $428,218 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop subcellularly resolved spatial genomics approaches for studying axon regeneration. The research maps the nerve regenerative landscape by building a three-dimensional spatial single-cell transcriptomics atlas of dorsal root ganglia in mice, training a...
- The National Institute of Biomedical Imaging and Bioengineering awarded The Washington University $119,818 on July 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop AI-powered gradient echo plural contrast imaging (AI-GEPCI) technology for early detection and monitoring of progressive multiple sclerosis. The award funds development of an integrated neuroimaging platform that combines deep learning with...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded $150,342 to the University of Washington on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds investigation of how long-term, closed-loop, epidural spinal cord stimulation affects neuropathic pain symptoms in rats with cervical spinal cord injury. The...
- The National Institute of Neurological Disorders and Stroke, a component of the Department of Health and Human Services National Institutes of Health, awarded a cooperative agreement to The Johns Hopkins University for $749,720 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The funding supports development and preclinical testing of a sustained-delivery insulin-like growth factor 1 (IGF-1) therapeutic for...
The National Institute of Neurological Disorders and Stroke awarded Washington University in St. Louis $493,332 on August 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop a surface electroneurography device for in-office assessment of peripheral nerve recovery. Washington University partnered with Biocircuit Technologies to design a diagnostic system addressing limitations in current peripheral nerve injury evaluation. Existing nerve conduction studies and electromyography require expert training and struggle to localize lesion sites; after high-grade axonotmetic injury, detection of nerve recovery depends on regeneration reaching target organs with measurable evoked responses, creating diagnostic delays that compromise surgical intervention timing and patient outcomes. Ultrasound can distinguish nerve transection from crush injury but poorly discriminates degree of crush injury or recovery prognosis. The surface electroneurography system aims to improve nerve injury localization and recovery tracking to enhance prognostic capability for the approximately 100,000 upper extremity peripheral nerve injuries occurring annually in the United States. Performance occurs in St. Louis, Missouri, with a period of performance from August 1, 2026, through July 31, 2028. The award is classified as a Project Grant, an assistance type supporting discrete research objectives.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $493.3k | 7/30/26 |