This federal Project Grant award from the National Institute of Mental Health (CFDA 93.242 - Mental Health Research Grants) provides $884,103 to the University of California, San Diego (UCSD) to study the use of a ketogenic diet as a potential treatment for individuals who have recovered from anorexia nervosa.
The key objectives are to: 1) Establish biological targets and evaluate the safety/tolerability of a therapeutic ketogenic diet in weight-recovered anorexia nervosa patients (R61 phase), and 2) Replicate the target engagement findings and link the biological measures to eating disorder-specific behaviors in a larger patient cohort (R33 phase). The project will utilize brain imaging techniques like PET scans to assess changes in glucose metabolism associated with the ketogenic diet intervention. Researchers will also examine the correlation between the biological measures and clinical outcomes related to eating restraint, weight concerns, and overall impairment. The award period runs from July 2024 through May 2026.
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