This Project Grant award, funded by the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310), provides $694,434 to Colorado State University to refine and test the EXPO (Executive Function Play Opportunities) intervention, a 12-week caregiver-mediated program designed to strengthen executive function in young children with Down syndrome. The project aims to transform EXPO into an adaptive intervention to better meet the needs of children with varying developmental delays. During the initial R61 phase, the university will incorporate usability feedback and preliminary efficacy data to refine the intervention structure and materials. The subsequent R33 phase will test two adaptive EXPO pathways - lengthening the duration and augmenting the intervention with activities to strengthen play foundations. The University of Padova in Italy will serve as a sub-awardee, responsible for intervention development, piloting, data collection, and analysis in a parallel study to assess cross-cultural efficacy. The findings from this R61/R33 project are intended to yield a novel adaptive executive function intervention for young children with Down syndrome, paving the way for a larger randomized controlled trial.
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