Project Grant R61AI197035
- Federal Project Grant Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of North Carolina at Chapel Hill $1,414,502 on August 1, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to assess antiretroviral (ARV) tissue penetration variability using multimodal imaging techniques. This five-year project (concluding July 31, 2030) investigates how HIV persists in tissue viral reservoirs during antiretroviral treatment and how...
- Federal Grant Award Summary The University of North Carolina at Chapel Hill received a $2.94 million Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded on August 18, 2025, with a completion date of July 31, 2029. This award supports the development and clinical advancement of ACE2 immunodecoys as long-lasting immunoprophylaxis against sarbecoviruses and merbecoviruses that target...
- Federal Grant Award Summary The University of North Carolina at Chapel Hill received a $1.37 million Project Grant from the National Institute of Mental Health under the Mental Health Research Grants program (CFDA 93.242) effective September 23, 2025, through September 22, 2028. The grant funds the "RELAI" (Reaching Persons with HIV Who Are Out of Care Through Expedited Access to Long-Acting Injectable Antiretroviral Therapy) study, which evaluates field-based delivery of long-acting...
- Federal Grant Award Summary The University of North Carolina at Chapel Hill received a $233,250 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded on May 13, 2025, with completion targeted for April 30, 2027. This award supports the development and characterization of self-circulating non-replicating bacteriophages (SCNRPVs) as a novel gene therapy platform for targeted...
- Federal Project Grant Award Summary Duke University's Office of Research Administration received a $208,875 Project Grant from the National Institute of Allergy and Infectious Diseases under the Allergy and Infectious Diseases Research program (CFDA 93.855) for the period August 1, 2025 through July 31, 2028. The grant supports research and development of a multivalent messenger ribonucleic acid (mRNA) HIV vaccine designed to elicit broadly neutralizing antibodies (BNAbs) targeting conserved...
- Federal Grant Award Summary The University of North Carolina at Chapel Hill received a $703,675 Project Grant from the National Institute on Drug Abuse under the Drug Use and Addiction Research Programs (CFDA 93.279) to develop and test innovative therapeutic approaches for HIV reservoir inactivation in the central nervous system (CNS). The award, effective August 15, 2025, through May 31, 2030, supports research focused on creating microglia-targeting lipid nanoparticles (LNPs) containing...
- Federal Grant Award Summary Georgia TECH Research Corp received a $725,241 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded February 2, 2026, with completion targeted for January 31, 2031. The award supports research into controlled delivery of adjuvanted multivalent fusion peptide-focused human immunodeficiency virus (HIV) vaccines. The project integrates five complementary...
- Federal Grant Award Summary The University of North Carolina at Chapel Hill received a $190,825 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective February 10, 2026, with completion targeted for January 31, 2028. This award supports research applying novel genomic and bioinformatic tools to distinguish Plasmodium vivax malaria relapses from re-infections in clinical trial...
- Federal Grant Award Summary The University of North Carolina at Chapel Hill received a $427,625 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded February 6, 2026, with completion targeted for January 31, 2028. The award funds development of a rapid point-of-care lateral flow strip assay (LFSA) device for detecting Herpes Simplex Virus (HSV) infections in both symptomatic and...
- Federal Project Grant Award Summary The University of Pittsburgh received a $790,847 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded February 10, 2026, with completion targeted for January 31, 2031. This award supports investigative research into HIV-1 resistance pathways against lenacapavir (LEN), a potent capsid inhibitor approved for both treatment and prevention of HIV...
The University of North Carolina at Chapel Hill received a $1,106,984 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective April 14, 2026, through March 31, 2028. The award supports comprehensive evaluation and translation of an ultra-long-acting in-situ forming implant (ISFI) as a subcutaneous injectable multipurpose prevention technology (MPT) designed to simultaneously provide protection against HIV infection and unplanned pregnancy. This research addresses a critical global health need, particularly for women who comprise over 50% of HIV-infected individuals worldwide and experience high rates of unplanned pregnancies. The project focuses on advancing injectable formulation delivery systems that overcome current limitations of existing long-acting HIV pre-exposure prophylaxis (PrEP) medications, such as Apretude, which requires multiple annual injections. By developing a first-in-line injectable MPT that combines multiple therapeutic agents into a single injection, the research aims to improve patient compliance, enhance privacy protection, and reduce "pill fatigue" associated with daily oral medication regimens. The deliverables include technical development, clinical evaluation, and translational advancement of this female-controlled contraceptive and HIV prevention technology with potential for global health impact.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.1m | 4/17/26 |