Project Grant R61AG096085
- This federal Project Grant award of $240,069 from the National Institute on Aging (CFDA 93.866 - Aging Research) to Vanderbilt University will be used to explore the effects of lifestyle on immune system activity and molecular markers of aging across populations with diverse lifestyles, from traditional subsistence-level to highly urban. The research will focus on analyzing three age-associated molecular phenotypes - gene expression, DNA methylation, and telomere length - in peripheral blood...
- This Project Grant award of $380,000.00 was provided by the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to Northern Illinois University to investigate mechanisms underlying treatments for adolescent social stress. The research project aims to compare neural mechanisms of a social resocialization treatment strategy versus an environmental enrichment approach to promote stress resilience, using the socially monogamous prairie vole as a translational...
- This federal Project Grant award of $291,913 was provided by the National Institute on Aging (CFDA 93.866 - Aging Research) to Virscio, Inc., a for-profit research company located in Connecticut. The award is focused on developing epigenetic and senescent biomarkers using non-human primate tissues to advance the understanding of biological aging processes and potential anti-aging strategies. The project aims to create minimally invasive biomarker tools, such as blood and skin-based assays,...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to identify which aspects of daily stress processes - frequency, severity, and affective reactions - are linked with heightened inflammatory biomarkers in older adults, and the extent to which these associations vary between men and women. The award of $148,500 will be used by the primary awardee, South Dakota State University, to conduct this research using data from the Einstein Aging Study. The...
- This $2,991,725 Project Grant award, provided by the National Institute on Aging (CFDA 93.866 Aging Research), supports research into the role of reactive oxygen species as modulators of lifespan and age-related diseases. The 4-year project, which commenced on September 1, 2025, aims to investigate a novel longevity paradigm in C. elegans that is triggered by early-life oxidative stress and mediated by changes in the epigenetic landscape. The research will examine the conserved mechanisms...
- This federal Project Grant award of $203,278.00, provided by the National Institute on Aging under the Aging Research program (CFDA 93.866), will fund research to understand the behavioral and neurobiological mechanisms underlying age-related shifts in motivation and their impact on daily life activity participation in older adults. The research will employ a multilevel, multimodal approach, utilizing behavioral, psychophysiological, neuroimaging, and naturalistic assessment methods to...
- This $562,314 federal Project Grant awarded by the National Institute on Aging under the Aging Research program (CFDA 93.866) supports a 3-year study to identify risk and protective factors associated with psychosocial resilience in spousal caregivers for spouses with Alzheimer's disease and related dementias. The study leverages data from several large, longitudinal cohort studies, including the Health and Retirement Study, to examine how caregivers' well-being, mental health, and cognitive...
- This $846,358 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to build a research platform to assess the senescence-associated secretory phenotype (SASP) in vivo. The goal is to elucidate the molecular identity of the SASP secretome and develop biomarkers to distinguish senescence and SASP signatures across different tissues. To accomplish this, the award will leverage a novel SASP-ER platform that permits conditional tagging of secreted proteins in...
- This Project Grant award of $387,006 from the National Institute on Aging (NIA) under CFDA Program 93.866 - Aging Research supports research to understand how indoles derived from commensal gut bacteria can promote mobility and counteract sarcopenia (age-related muscle wasting) in aging animals. The research aims to determine the mechanisms by which indoles regulate muscle protein homeostasis, mitochondrial function, and other cellular pathways to maintain muscle mass and function during...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $699,344 to Albert Einstein College of Medicine to investigate the impact of surgical stress on age-related changes and resilience, with a focus on sex differences. The project aims to quantify the spatial, temporal, and sex-dependent effects of surgical stress on aging hallmarks and determine how resilience may modulate these relationships. The 2-year award period runs from September 1, 2025 to...
This $694,172 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to examine the impacts of social resilience on immunometabolic hallmarks of aging in prairie voles. The key products and services to be delivered through this award include: 1) Using unbiased metabolomics and targeted analysis of inflammatory markers to identify changes in global metabolic state and specific hallmarks of aging, such as mitochondrial dysfunction and senescence profiles, in chronically socially isolated prairie voles compared to socially housed animals; and 2) Correlating these metabolic phenotypes with behavioral assessments to develop a social resilience index that associates social function with physiological markers of health and aging. This research aims to provide insights into how variation in response to chronic social isolation stress may contribute to differences in social resilience and modify the physiological response to stress with age.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $694.2k | 8/6/25 |