The University of Kansas Medical Center Research Institute, Inc. (KUMCRI) was awarded a $1,489,256 Project Grant from the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866). The grant aims to investigate the effects of a ketogenic diet on brain energy metabolism in aging and Alzheimer's disease.
The project has two phases: 1) the R61 developmental phase, where the researchers will develop advanced magnetic resonance spectroscopy techniques to measure biomarkers of brain bioenergetics, including ketone levels, NAD/NADH, and ATP/phosphocreatine; and 2) the R33 basic experiment study phase, where the researchers will utilize the developed imaging techniques to quantify the impact of a ketogenic diet on brain energy metabolism, antioxidant status, and neuroenergetic changes in aging and Alzheimer's disease. The award is effective from July 15, 2024 through June 30, 2026.
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