This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $3,085,041 to the University of Pittsburgh to conduct longitudinal research on adolescent brain maturation and its relationship to psychopathology. The key objectives are to: Examine neuropil growth/contraction using 3D whole-brain phosphorus magnetic resonance spectroscopy (31P MRS) Elucidate alterations in multiple modalities of brain...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), aims to investigate the developmental origins of mental illness by studying the structure and function of the human hypothalamus. The $392,500 award to the University of California, Irvine will fund a 5-year research project that will: 1) develop normative brain imaging measures of hypothalamic development from birth to adulthood, 2) assess the impact of...
The National Institute of Mental Health (NIMH) awarded a $2,220,017 Project Grant (CFDA 93.242 - Mental Health Research Grants) to the Lieber Institute for Brain Development in Baltimore, Maryland. The grant's objective is to generate single-cell transcriptomic profiles to study molecular changes associated with major depressive disorder (MDD) in the mood regulation circuitry of the brain, including the anterior cingulate cortex, basolateral amygdala, and hippocampus. The research aims to...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), will support research to investigate how unpredictability in early parental behavior influences the development of emotion regulation and brain function in children, and their subsequent risk for psychopathology. The $176,638 award to The Washington University will fund a longitudinal study from birth to age 8 that leverages existing behavioral, brain...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $133,488 to the University of California, Los Angeles (UCLA) to investigate the effects of early life adversity on the developmental trajectory of avoidance circuitry. The key objectives are to reveal the activity of early life adversity-sensitive neuron ensembles in the basolateral amygdala during threat avoidance behavior, map their brain-wide...
This Project Grant award for $497,652 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will support research conducted by Children's Research Institute to investigate the role of the FOXP2 gene in the development of social circuitry and behavior in the amygdala during adolescence. The research aims to use CRISPR-Cas gene editing techniques to delete the FOXP2 gene in the medial amygdala of male and female mice during adolescence....
This federal Project Grant award of $667,250 was provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The grant will fund research at Michigan State University to study the hormonal programming of the mesocorticolimbic dopamine circuit during adolescent development. The research aims to investigate how gonadal hormones influence the adolescent maturation of dopaminergic axons connecting the nucleus accumbens and medial...
The National Institute of Mental Health (NIMH) awarded a $367,708 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to the University of Southern California (USC). The grant, awarded on September 3, 2024, supports a 5-year research project titled "Neural Substrates of Autism and ADHD: Reward Circuitry Connectivity and Individual Differences". The project aims to use cutting-edge neuroimaging and machine learning methods to investigate how the functional...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), is focused on elucidating how POMC neurons in the hypothalamus respond to and regulate social behaviors during development. The total funding amount is $461,084, awarded on June 16, 2025 with an ultimate completion date of June 15, 2027. The principal investigator and awardee is Yale University, a prestigious private research university. The key products...
This federal Project Grant award of $165,980 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research on neural indices of social and monetary reward processing as predictors of real-world pleasure and affect in adolescents at risk for depression. The study aims to examine event-related potential (ERP) indices of social and monetary reward processing in adolescents with a maternal history of major depressive disorder...