Project Grant R56HL174856

Award Date 9/20/24
Completion Date 8/31/25
Dollars Obligated $547K
Federal Grant Program
93.837
Assistance Type
Project Grant
Place of Performance
Denton, TX 76203, USA
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This Project Grant award for $547,020.00, provided by the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), aims to establish an Organoid-AI system for assessing cardiotoxicity induced by Tyrosine Kinase Inhibitors (TKIs) used in cancer treatment.

The central goal is to develop a comprehensive in vitro human model using Pluripotent Stem Cell-derived Vascularized Cardiac Organoids (VCOs) to accurately predict and phenotype TKI-induced cardiovascular structural and functional toxicity. This will involve utilizing Generative AI algorithms to predict TKI-induced toxicity on cardiovascular structure, characterizing TKI-induced cardiovascular dysfunction in VCOs, and integrating these capabilities into an efficient and accurate Organoid-AI assessment system for preclinical drug safety evaluation.

The project will be conducted in collaboration with a sub-awardee, the University of Texas Southwestern Medical Center, which will contribute to developing the Organoid-AI system for comprehensive assessment of TKI-induced cardiotoxicity. The award period is from September 20, 2024 to August 31, 2025.

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