The federal Project Grant award of $620,371, provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), will fund research to determine the voltage-sensing domain (VSD) dynamics of cardiac ion channels from the CNBD family, which play a pivotal role in regulating the electrical properties of the heart. The overarching objective is to leverage advanced biophysical techniques, including patch-clamp fluorometry, transition metal ion FRET, and fluorescence lifetime imaging, to characterize the structural rearrangements and conformational dynamics of these channels. This research aims to elucidate the mechanisms underlying cardiac diseases related to CNBD channels, such as atrial/ventricular arrhythmias and long QT syndrome, in order to pave the way for new therapeutic approaches. The award period runs from Sep 21, 2024 to Aug 31, 2026, and includes a sub-award to the University of Illinois to perform supporting molecular dynamics simulations.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $0 | 7/8/25 | ||
| Not listed | $620.4k | 9/21/24 |
Grant Number | Description | Subgrantee | Prime Award | Dollars Obligated (Click to sort descending) | Updated At (Click to sort ascending) |
|---|---|---|---|---|---|
A0225723950S | University Of Illinois | Project Grant R56HL169176 | $194.4k | 10/18/24 |