The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $395,171 Project Grant (CFDA 93.846) to Rush University Medical Center to determine the in vivo chemical alteration processes of contemporary ultra-high molecular weight polyethylene (PE) tibial liners used in total knee arthroplasty (TKA), and their impact on mechanical properties, wear behavior, and onset of osteolysis. The research aims to enhance preclinical methods for predicting PE-induced osteolysis and maximize implant longevity. A $92,004 sub-award was provided to Trustees of Dartmouth College to support this research. The project will run from Sep 1, 2024 to Aug 31, 2025.
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