Project Grant R56AG082808

Award Date 9/15/23
Completion Date 8/31/24
Dollars Obligated $387K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Houston, TX 77030, USA
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This federal Project Grant award of $507,325 from the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of Texas Health Science Center at Houston (UTHealth) aims to examine the role of ROR (Retinoid Acid Receptor-Related Orphan Receptor) nuclear receptors in regulating mitochondrial function and skeletal muscle aging. The key objectives are to: Comprehensively investigate the age- and circadian time-dependent changes in mitochondrial activity and homeostasis in...
This $653,189 federal Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) supports research at The University of Texas Southwestern Medical Center to investigate the impact of caloric restriction and circadian rhythms on healthspan and lifespan. The grant aims to determine whether time-restricted feeding without caloric restriction can extend lifespan, whether enhancing clock gene expression can improve health and lifespan, and whether the cytokine...
This Project Grant award from the National Institute on Aging's Aging Research Federal Grant Program (CFDA 93.866) provides $241,500 to the University of California, Davis to investigate the post-translational mechanisms that mediate metabolic regulation of daily biological rhythms. The project aims to identify proteins that are rhythmically modified by the nutrient-sensitive post-translational modifications (PTMs) of O-GlcNAcylation and phosphorylation, and assess how the timing of metabolic...
The federal Project Grant award R56AG080294 in the amount of $440,000.00 was provided by the National Institute on Aging under their Aging Research program (CFDA 93.866). The grant supports research at the Beckman Research Institute of the City of Hope aimed at understanding the role of circadian clock regulation in the development of sarcopenic obesity, which is the loss of skeletal muscle mass and function with obesity in older adults. The research will employ transcriptomics and...
This $592,507 project grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) to Tufts University School of Medicine aims to develop metabolomic clocks as a tool to explore mechanisms of aging. The key products and services to be delivered include: Developing sex- and tissue-specific metabolome clocks in the Drosophila model system to serve as biomarkers of aging with high translational potential. Determining the significance of metabolome clock components as mechanisms...
This $745,418 Project Grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) to the Buck Institute for Research on Aging will support research to determine the molecular mechanisms that slow age-related decline in visual system function, with a focus on the role of dietary restriction and circadian clocks. The study aims to delineate the diet and aging-dependent genes, including circadian transcriptional networks and their outputs, involved in phototransduction...
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This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $429,000 to the Regents of the University of Michigan to conduct research on non-canonical mechanisms and unconventional approaches to activate AMP-activated protein kinase (AMPK) and improve glucose uptake in the skeletal muscle of older rats. The key objectives are to: 1) Determine the effects of caloric restriction on AMPK regulators and activation in skeletal muscle subcellular...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $451,000.00 to The University of Texas Southwestern Medical Center to conduct research on the role of the p38 MAPK signaling pathway in regulating lysosome function and tissue integrity during development and aging. The key objectives are to: 1) define the p38 MAPK interactome required for lysosome regeneration, 2) reveal tissue and stage-specific functions of p38 MAPK in lysosome regeneration...
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This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $386,900.00 to the University of Texas Health Science Center at Houston (UTHealth) to study the role of the circadian clock and retinoid acid receptor-related orphan receptor (ROR) proteins in regulating metabolic function and healthy aging.

The key objectives are to: 1) Evaluate the impact of ROR proteins on healthspan and lifespan using mice with skeletal muscle-specific ROR knockout, 2) Determine the regulatory pathways by which RORs orchestrate energy metabolism and mitochondrial function in aged mice, and 3) Assess whether the healthy aging effects of time-restricted feeding and timed exercise interventions are dependent on RORs. The proposed research combines physiological, molecular, and omics approaches to provide mechanistic insights on the interplay between circadian rhythms, metabolism, and the gene regulatory hallmarks of aging. The findings could inform the development of new therapeutic strategies to promote healthy aging by targeting the circadian clock.

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