This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $507,325 to the University of Texas Health Science Center at Houston to investigate the role of circadian rhythms and ROR nuclear receptors in regulating mitochondrial function and skeletal muscle aging. The 5-year project aims to elucidate the mechanisms by which ROR proteins control age-related changes in mitochondrial activity and gene expression, as well as evaluate the efficacy of...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $386,900.00 to the University of Texas Health Science Center at Houston (UTHealth) to study the role of the circadian clock and retinoid acid receptor-related orphan receptor (ROR) proteins in regulating metabolic function and healthy aging. The key objectives are to: 1) Evaluate the impact of ROR proteins on healthspan and lifespan using mice with skeletal muscle-specific ROR knockout, 2)...
This federal Project Grant award, titled "Untangling the Bidirectional Relationship Between the Spread of Pathological Protein Aggregates, Sleep, and Circadian Clock Disruption in Neurodegenerative Disease," is funded by the National Institute on Aging (CFDA 93.866 Aging Research) for $762,733. The primary goal is to investigate the mechanisms by which disrupted sleep and circadian timing contribute to the formation and spread of pathogenic tau and alpha-synuclein proteins in...
This Project Grant award for $592,507 from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund research to develop and utilize metabolomic clocks as a tool to explore the mechanisms of aging. The primary awardee, Trustees of Tufts College (Tufts University School of Medicine), will pursue three specific aims over the 5-year project period from Sep 2024 to Jun 2029: Develop sex- and tissue-specific metabolome clocks for the model organism Drosophila to predict and explain...
The federal Project Grant award of $159,512.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research at the University of Florida to investigate the role of the kynurenine pathway and aryl hydrocarbon receptor (AhR) activation in age-related physical decline and frailty. The research will use novel genetic mouse models to test if elevated levels of L-kynurenine, reduced skeletal muscle L-kynurenine degradation, and chronic AhR activation contribute to the...
This $1,294,013 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a multi-year clinical trial and associated research examining the impact of biological aging mechanisms on exercise response variability in older adults. The principal investigator will conduct a randomized trial of a 6-month resistance training intervention and a health education control, focusing on two co-primary outcomes: physical function and insulin sensitivity. The project will...
This $241,500 Project Grant awarded by the National Institute on Aging (CFDA 93.866 Aging Research) to the University of California, Davis (UC Davis) will investigate post-translational mechanisms that mediate metabolic regulation of time-of-day protein functions to orchestrate daily biological rhythms. The research aims to: 1) Identify proteins that are rhythmically modified by O-GlcNAcylation and phosphorylation in key mammalian organs, and examine how rhythmic post-translational...
This is a Project Grant award from the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866). The $107,948 award supports research to investigate the mechanism by which mitochondrial protein import stress can induce the release of beneficial myokines, which are signaling molecules produced by muscle cells. The 5-year project aims to uncover how this mitochondrial stress pathway activates myokine expression and determine if the induced myokines can promote...
This $146,816 Project Grant was awarded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The grant, running from July 1, 2025 to June 30, 2028, will support research to investigate the role of the muscle circadian clock in cancer cachexia, a debilitating condition affecting up to 80% of cancer patients. The research aims to define how disruptions in the muscle clock...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $116,710 in funding to Duke University to conduct research aimed at understanding the role of fibro/adipogenic progenitor (FAP) cells in age-related muscle fibrosis and developing therapeutic strategies to counteract muscle weakness in sarcopenia. The award period runs from August 1, 2024 to July 31, 2029. The key objectives of the research are to: 1) determine the timeline of FAP fibrogenesis...