Project Grant R50CA305054
- This $204,027 federal Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) is supporting the Weill Medical College of Cornell University in expanding single-cell and spatial technologies to link clonal genotypes with phenotypes during cancer evolution. The grant aims to develop advanced single-cell methods that can capture multiple data modalities, including genotypes, transcriptomes, methylomes, and protein expression, to better understand how somatic...
- This federal Project Grant award of $418,176 from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) supports the development and validation of a novel approach called "Programmable Nucleic Acid Cytometry" at the Sloan-Kettering Institute for Cancer Research. The project aims to advance this innovative method for profiling rare cell populations from tumors and tissues, which offers advantages over traditional antibody-based cell isolation techniques. The work will...
- This federal Project Grant award, valued at $401,829.00 and awarded by the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396), supports innovative research by Weill Medical College of Cornell University to develop transformative methods for high-throughput single-cell mapping of DNA-binding proteins. The project, titled "Precision Single-Cell Mapping of Chromatin-Associated Protein Activity by Molecular Footprinting to Chart Disruptions to Gene Regulation...
- This $292,028 Project Grant awarded by the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower) supports research to investigate the mechanisms by which oncogene amplification leads to genome instability and the development of therapy-resistant cancer clones. The research will be conducted by the Sloan-Kettering Institute for Cancer Research in New York and is scheduled to run from August 1, 2025 to July 31, 2030. Using single-cell genomic sequencing techniques, the project aims...
- The federal Project Grant award of $202,982.00 was provided by the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower) to Cold Spring Harbor Laboratory to conduct research aimed at "Understanding and Targeting Senescence in Clonal Hematopoiesis". The research project seeks to identify inflammatory mediators and cell-autonomous pathways in clonal hematopoiesis (CH) that may serve as potential therapeutic targets to restore oligoclonal hematopoiesis and address the adverse...
- The National Cancer Institute (CFDA 93.396 - Cancer Biology Research) awarded a $1,625,853 Project Grant to New York University (NYU) on December 13, 2024. The grant will support NYU's research to map and characterize the role of 3D "hubs" - regulatory DNA elements that interact with multiple loci - in the context of T-cell leukemia (T-ALL), early T-cell progenitor leukemia (ETP-ALL), and T-cell lymphoma. The project aims to better define how these 3D chromatin structures are rewired...
- The National Cancer Institute (CFDA 93.393 - Cancer Cause and Prevention Research) awarded a $3,201,530 Project Grant to the Sloan-Kettering Institute for Cancer Research to investigate the mechanisms underlying extrachromosomal DNA (ecDNA) segregation and repair in cancer. The key focus areas include: Exploring how the circular topology of ecDNA affects its function and maintenance, specifically examining the RNA-dependent physical tethering of ecDNA to mitotic chromosomes that facilitates...
- This $238,722 federal Project Grant awarded on August 18, 2025 by the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower) to the Sloan-Kettering Institute for Cancer Research supports research to investigate the role of mutagenic DNA repair during the persistence of cancer cells. The research aims to define the specific mechanisms that promote mutagenic DNA repair and drive acquired drug resistance in persister cancer cells, focusing on the role of the microhomology-mediated end...
- The federal Project Grant award of $1,749,106 from the National Institutes of Health (NIH) Trans-NIH Research Support Program (CFDA 93.310) supports research at Cold Spring Harbor Laboratory (CSHL) to investigate the role of nuclear speckles in gene regulation. The research aims to identify new transcription factors that drive DNA-speckle association, determine the importance of this function for diseases like cancer and inflammation, and develop ways to inhibit it using chemical compounds....
- This federal Project Grant award from the National Cancer Institute (CFDA 93.393 - Cancer Cause and Prevention Research) supports research by the Stowers Institute for Medical Research to investigate the impact of natural variation in human centromeric DNA sequences and epigenetic patterns on chromosome segregation and genome integrity. The $125,619 grant, awarded on August 1, 2025, will fund research over a 5-year period to map centromeric DNA landscapes and associated kinetochore proteins...
This federal Project Grant award from the National Cancer Institute (NCI) under CFDA 93.396 (Cancer Biology Research) provides $182,755 to Cold Spring Harbor Laboratory (CSHL) to conduct research on genetic technology development for understanding lineage plasticity mechanisms in cancer. The award began on August 21, 2025 and is scheduled for completion on July 31, 2030. The key products and services to be delivered through this grant include: 1) developing a CRISPR screening methodology for identifying redundant epigenetic and signaling regulators in cancer, 2) creating genetic screening platforms to reveal novel epigenetic regulators of cell fate, and 3) applying deep-mutational scanning technology to map functional and non-functional mutations in transcriptional regulators. This research aims to advance scientific knowledge of fundamental biological mechanisms underlying cancer development, progression, and potential therapeutic interventions.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $182.8k | 8/21/25 |