Project Grant R50CA293845
- The federal Project Grant award of $1,602,000.00 from the National Institute of Environmental Health Sciences, under the Medical Library Assistance program (CFDA 93.879), will support the development of computational methods for analyzing multiplex immunofluorescence (MIF) imaging data to study the tumor microenvironment. The project aims to leverage a unique MIF dataset from over 2,000 cancer patients across 20 tumor types to develop innovative computational strategies, including spatial...
- The Project Grant award of $424,734 from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) supports the development of a novel spatial proteomics approach to profile immune cell types and their locations within a tumor microenvironment. The University of Illinois, the awardee, aims to integrate 3D microscopy techniques with bottom-up proteomic assays to offer deep proteome profiles of specific immune cells at various subregions of a mouse tumor (Aims 1 and 2). The goal is...
- This federal Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) provides $632,300 to Carnegie Mellon University to develop an integrated ultrahigh-throughput 3D volumetric super-resolution imaging system. This system will combine a multiscale fluorescence mesoscope with expansion microscopy to enable rapid, large-area 3D imaging at subcellular resolution. The goal is to advance the application of spatial biology in cancer research by visualizing...
- This $375,134 Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) supports research to develop a novel approach for reducing the off-target accumulation of chemotherapeutic nanomedicines. The key objectives are to characterize an innate immune response that can be leveraged to limit nanoparticle deposition in healthy tissues, thereby enhancing delivery to tumors and improving the efficacy of chemotherapy. The 5-year project, starting on March 1, 2025,...
- The University of Chicago received a $372,628 Project Grant from the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) on September 12, 2025. The grant funds the development of a large-format spatial transcriptomics profiling platform, called Array-Seq, to enable detailed spatiomolecular analysis of human cancer samples. This technology aims to overcome limitations of existing spatial transcriptomics methods by increasing throughput, sample size compatibility, and...
- This federal Project Grant award of $2,053,480.00 was provided by the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), to The Regents of the University of Colorado, doing business as the University of Colorado-Denver. The project aims to develop a novel framework for analyzing pathway interactions and pathway-phenotype associations in bulk and single-cell RNA sequencing (RNA-seq) studies. The key products or...
- The federal Project Grant award of $369,564.00 was provided by the National Cancer Institute (NCI) under the Cancer Research Manpower (CFDA 93.398) program. The award supports the "STUDENTS AND TEACHERS ACHIEVING CANCER RESEARCH EXPERIENCES TOGETHER (START) PROGRAM" aimed at expanding representation of underserved secondary school students in science careers through cancer research and education initiatives in the community surrounding the University of Colorado Anschutz Medical Campus...
- This $421,685 federal Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) supports research conducted by the University of California, San Francisco (UCSF) to investigate the "reactive" immune system in tumors and the tumor microenvironment. The study aims to discover discrete immune cell niches within the tumor that can enhance the effectiveness of cancer immunotherapies. Using innovative spatial transcriptomics, genetic tools, and cellular...
- The University of Pittsburgh was awarded a $408,829 Project Grant from the National Cancer Institute (CFDA 93.396 Cancer Biology Research) to develop an "Integrative Framework for Surface Protein Imputation for Spatial Biology of Cancer". The goal of the project is to increase the utility of spatial transcriptomics datasets by imputing surface protein abundance through incorporating spatial and histological dependencies, and simultaneously learning the RNA-protein mapping relation from...
- This federal Project Grant award of $204,474, awarded by the National Cancer Institute (CFDA 93.398 Cancer Research Manpower program), is supporting research to define the transition from deep cell quiescence to senescence. The University of Colorado, the awardee, will use time-lapse microscopy and molecular assays to investigate the mechanisms controlling quiescence depth and the relationship between deep quiescence and senescence. The research aims to determine if senescence is a form of...
This federal Project Grant award of $584,510.00, provided by the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396), supports the development of advanced spatial transcriptomics and proteomics technologies for studying tumor microenvironments. The award enables the University of Colorado-Denver to implement new imaging techniques and computational approaches to enhance the capabilities of its Human Immune Monitoring Shared Resource (HIMSR). This will allow HIMSR to provide cutting-edge services to support cancer-related clinical trials, including sample processing, assay optimization, and primary data analysis. The funding will also facilitate the continued advancement of existing multiplex imaging technologies and the development of novel computational tools for image analysis. The award period runs from Sep 12, 2025 through Aug 31, 2029, during which the university will work to expand its expertise in spatial omics and leverage this expertise to benefit cancer research and clinical trials at the University of Colorado Cancer Center.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $584.5k | 9/11/25 |