Project Grant R44HL137487

This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $298,371 to Anova Biomedical, Inc. to develop a new class of biodegradable and elastic vascular grafts for hemodialysis access. The key products and services to be delivered include: Refining manufacturing techniques to produce vascular grafts with distinct arterial and venous zones using a novel, fully...

This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $738,356 to the University of Pittsburgh to optimize and prepare for clinical translation of their tissue-engineered vascular graft (TEVG) technology. The project aims to perform final in vitro assessments and in vivo validation of scaled-up, human-sized TEVG constructs using a silk scaffold seeded with extracellular vesicles (EVs)...

This $274,547 Project Grant awarded by the National Science Foundation (NSF) under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program aims to develop a novel Aneurysm Sealing Device (ASD) for endovascular treatment of Abdominal Aortic Aneurysms (AAA). The project seeks to create a device that can completely seal the aneurysm sac, reducing the risk of post-procedure complications and the need for repeat interventions. Key objectives include validating the device's adaptability...

This Project Grant award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) provides $274,811 to Anova Biomedical, Inc. to develop 3D printed personalized vascular grafts using novel elastomeric resins. The key objectives are to: 1) develop and characterize the novel 3D printing resin for producing personalized, elastic, and bioresorbable vascular grafts; 2) demonstrate the ability to 3D print vascular prosthetics using patient CT...

This Cooperative Agreement award of $2,252,419.00, granted by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), supports the development of an innovative vascular conduit device for dialysis vascular access. The project, led by the University of North Carolina at Chapel Hill, aims to create the "Functional Integrated Electrospun (FINE) Device" -...

Endoshape, Inc. was awarded a $370,938 project grant from the National Heart, Lung, and Blood Institute of the National Institutes of Health to develop radiopaque shape memory polymers for neurovascular embolotherapy applications. The Cardiovascular Diseases Research program aims to support heart and vascular research, including through competitive research training grants. Under this award, Endoshape will develop new radiopaque shape memory polymer materials incorporated into embolic coils....

This Project Grant from the National Institutes of Health's National Institute of Biomedical Imaging and Bioengineering will fund research at Hofstra University related to the development of plant-based vascular grafts. With $790,800 in funding over three years from August 2022 to July 2025, the university will pursue tissue engineering techniques to decellularize plant leaves and condition them as scaffolds for vascular grafts. The research aims to create a nonthrombogenic graft that mimics the...

This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health (NIH), is for the development of an endovascular prosthetic graft device that integrates nitric oxide (NO)-releasing polymer technology. The goal is to create a device that can reduce the incidence of infection, neointimal proliferation, and thrombosis - the three main clinical complications associated with current endovascular stent grafts. The total funding...

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $499,890 Project Grant (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) to Pavaj Vascular Corporation to develop a novel therapy to prevent arteriovenous fistula (AVF) venous stenosis, a common complication in end-stage kidney disease patients requiring hemodialysis. The funding will support two main goals: 1) evaluating the stability and biocompatibility of a nanoparticle-based...

This federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $786,188 to Beth Israel Deaconess Medical Center, Inc. (BIDMC) to develop a novel biodegradable gene therapy hydrogel delivery system that can downregulate key genes driving intimal hyperplasia and prosthetic bypass graft failure. The project aims to optimize the hydrogel for sustained siRNA delivery, increased arterial adherence, and targeted vascular...