Project Grant R44GM165281
- The National Institute of General Medical Sciences awarded Photothermal Spectroscopy Corp. $306,802 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop a next-generation photothermal stimulated Raman scattering (PT-SRS) microscope for high-speed, label-free chemical imaging of live cells in standard multiwell culture plates. Current PT-SRS implementations use transmission geometries that prevent compatibility with inverted microscopes and...
- The National Institute of General Medical Sciences awarded N.p. Photonics, Inc., a Tucson, Arizona-based small business, $306,873 under the Biomedical Research and Research Training program (CFDA 93.859) on September 1, 2026, to develop a low-cost robust compact 900 nanometer femtosecond laser source for two-photon microscopy, featuring ultrashort pulse lasers with peak powers exceeding 1 kilowatt and specified pulse durations. The award obligates $306,873 and runs through August 31, 2027,...
- The National Institute of General Medical Sciences awarded Physical Sciences Inc. $311,847 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop a fluorescence-based rapid phage detection system for industrial bioreactors. Physical Sciences Inc. and the University of Connecticut are developing a lyobead assay platform that detects bacteriophage contamination in bioreactor systems within hours. The system uses a sampling chamber loaded with...
- The National Institute of General Medical Sciences awarded Molecular Instruments, Inc. $306,788 on September 30, 2025, under the Biomedical Research and Research Training program (CFDA 93.859) to advance probe technology for ultrasensitive RNA imaging via hybridization chain reaction (HCR). The project develops and refines in situ amplification methods based on HCR mechanism to overcome multi-decade limitations in RNA fluorescence in situ hybridization (RNA-FISH). Specifically, the work...
- The National Institute on Drug Abuse awarded Nefer Ka LLC $311,380 on July 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to develop economical, portable detection technology for illicit drugs in bodily fluids using surface-enhanced Raman scattering (SERS). The recipient will reduce costs and improve performance of SERS-based drug detection systems through two parallel technical approaches. First, Nefer Ka will leverage its scalable production technique to lower the...
- The National Institute of General Medical Sciences, part of the Department of Health and Human Services National Institutes of Health, awarded $323,090 to Tektonyx Bio, Inc. on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, Assistance Listing R43GM165195). Tektonyx Bio is developing a semi-synthetic organism platform for the production of next-generation protein therapeutics. The organism harbors two synthetic nucleotides that form an unnatural base...
- The National Institute of General Medical Sciences awarded Everest Biolabs, Inc. $1,153,043 under the Small Business Innovation Research Program (CFDA 93.859, Biomedical Research and Research Training) on September 1, 2026, to develop plate-based methods and materials for isolating extracellular vesicles from biofluids using dual-mode chromatography combining size exclusion chromatography with affinity-based depletion of common contaminants. The project will deliver high-performance,...
- The National Institute of General Medical Sciences awarded $300,001 to Vivid Bioinnovations, PBC on August 4, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop an integrated micro-robotic screening platform for high-throughput chemical reaction optimization and artificial intelligence model training. Vivid Bioinnovations will engineer a scalable platform combining micro-robotic nanoliter droplet dispensing with custom nanowell arrays and matrix-assisted...
- The National Institute of General Medical Sciences awarded $1.688 million to Pacific Northwest National Laboratory, a division of Battelle Memorial Institute, on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop a multimodal measurement platform for unambiguous lipid identification. The recipient will build a high-resolution ion mobility-mass spectrometry (IM-MS) system designed to distinguish free fatty acids and lipid isomers in complex...
- The National Institute of General Medical Sciences awarded Boston Interactome, Inc. $349,753 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop the Integrated Two-Hybrid (I2H) platform for protein-protein interaction mapping and drug discovery. Boston Interactome will develop I2H as a next-generation PPI detection platform combining multiple protein expression backgrounds and detection modes to achieve 80–90% coverage of protein-protein...
The National Institute of General Medical Sciences awarded Nirrin Technologies Inc. $1,156,172 as a Direct to Phase II Small Business Innovation Research (SBIR) Project Grant on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859). Nirrin Technologies will integrate its high-precision tunable laser spectroscopy (HPTLS) technology into liquid chromatography workflows to enable simultaneous identification and quantification of biopharmaceutical formulation components in a single analytical step. The company's Atlas-Flow platform will provide rapid quantification of proteins, nucleic acids, surfactants, sugars, amino acids, and other excipients without sample preparation. This integration addresses limitations in current LC detection methods—UV absorbance lacks chemical specificity for overlapping components, mass spectrometry requires costly infrastructure, and other detectors lack robustness for high-concentration formulations. The combined LC-HPTLS approach will reduce reliance on multiple orthogonal assays, lower costs, shorten product and process development timelines, and improve confidence in composition data for regulatory compliance. Performance takes place in Billerica, Massachusetts, with a period of performance extending from September 1, 2026, through March 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.2m | 8/10/26 |