Project Grant R44GM161192
- The federal Project Grant award of $420,000 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to identify the molecular mechanisms of mitochondrial dysfunction in pathological stress conditions. The primary objective is to investigate the processes of oxidative phosphorylation and mitochondrial membrane potential disruption, which can lead to cell death and tissue damage in various diseases....
- The project grant award of $1,925,000 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to investigate the structural dynamics and regulation of the mitochondrial pyruvate carrier (MPC) at Saint Louis University. The research aims to uncover the conformational changes of the MPC during pyruvate transport and inhibition using electron paramagnetic resonance (EPR) spectroscopy techniques, as...
- This federal Project Grant award of $237,874 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to investigate the upstream regulation of mitochondrial bioenergetics by the mitochondrial acyl carrier protein (MTACP). The research aims to uncover how MTACP, which sits at the intersection of nutrient inputs and energy expenditure in mitochondria, is regulated through the 4'-phosphopantetheine...
- This federal Project Grant award of $686,324, provided by the National Institute of General Medical Sciences (NIGMS) under CFDA Program 93.859 Biomedical Research and Research Training, supports mechanistic studies on the role of the E3 ubiquitin ligase MARCH5 in regulating mitochondrial and peroxisomal function. The grant recipient, the University of Maryland, Baltimore, will investigate how MARCH5 activity is vital for peroxisome biogenesis and how it protects mitochondria from the toxic...
- This $999,996 Project Grant award, provided by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074), supports fundamental research aimed at generating "designer mitochondria" for biotechnology, healthcare, and basic research applications. The key objectives are to identify the factors required for human mitochondrial DNA (mtDNA) replication and characterize the mechanisms underlying the species-specificity of this process. This work represents a critical step...
- The federal Project Grant award of $248,967.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research at the University of Massachusetts aimed at understanding mechanisms that control peroxisomal turnover and how peroxisome dysfunction signals to other cellular organelles. The project, awarded on July 10, 2025, with a completion date of June 30, 2028, will leverage recent findings on the role...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), focuses on developing a new class of proteolysis targeting chimeras (PROTACs) aimed at degrading Poly (ADP-ribose) Polymerase-1 (PARP-1) in diseased human cells. The $151,000 award to the Research Foundation of the City University of New York (RFCUNY) - Queens College will be used to design a library of PARP-1-targeting PROTACs and...
- This $3,227,502 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) is funding research at the University of Pennsylvania to investigate the role of mitochondrial dysfunction in myelodysplastic syndrome (MDS) caused by mutations in the SRSF2 splicing factor. The research aims to elucidate how SRSF2 mutations disrupt oxidative phosphorylation and activate the PINK1-mediated mitophagy pathway to enhance MDS cell survival. The findings...
- This federal Project Grant award, titled "DECODING MITOCHONDRIAL AAA PROTEASE SPECIFICITY", was provided by the National Institute of General Medical Sciences (CFDA 93.859 - Biomedical Research and Research Training) for $382,931 on September 1, 2025. The award supports fundamental scientific research and advanced training across diverse areas of biomedical science, with a focus on understanding biological processes and developing foundational knowledge for disease diagnosis,...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports research on the mechanisms of mitophagy, a form of mitochondrial quality control, and its role in promoting tissue health and homeostasis. The $373,129 award to Wayne State University will be used to generate genetic tools to manipulate different forms of mitophagy in the fruit fly model organism Drosophila melanogaster. The research...
This $1,016,229 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training program supports Perlara PBC's "REMIT (RESCUE MITOCHONDRIAL THERAPEUTICS): UNLOCKING BROAD-SPECTRUM MITOCHONDRIAL RESCUERS" research project. The project aims to screen 8,400 repurposable drugs and nutraceuticals using the Yarrowia lipolytica yeast model to identify therapeutic candidates capable of restoring mitochondrial function for the treatment of mitochondrial diseases. Promising compounds identified through these screens will undergo validation in human fibroblast models. The project builds on Perlara PBC's prior success in yeast-driven drug repurposing programs for rare genetic diseases, including a PMM2-CDG program that progressed from yeast-based discovery to a fully enrolled Phase III pivotal study in under 5 years. The award period is from September 12, 2025 to August 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.0m | 9/10/25 |