Project Grant R44GM159469
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $350,000 to Electronic Biosciences, Inc. to develop the first technology capable of high-accuracy sequencing of the RNA modifications pseudouridine (Ps) and N6-methyladenosine (M6A) using nanopore sequencing. The project aims to merge innovative bisulfite adduct methodology with Electronic Biosciences' enzyme-free, multipass...
- The National Institute of General Medical Sciences (NIGMS) awarded Epicypher, Inc. a $1,264,176 project grant under the Biomedical Research and Research Training federal grant program (CFDA 93.859) to develop a novel toolbox for studying how asymmetric post-translational modifications (PTMs) on nucleosomes regulate chromatin biology. The key products and services to be delivered include: A novel manufacturing method to efficiently generate asymmetric designer nucleosomes (A-dNucs) at...
- The National Institute of General Medical Sciences (NIGMS) awarded a $305,892 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Dotquant LLC, a biotechnology research and development company, to develop a new in vitro transcription kit for high-yield synthesis of chemically modified RNA. The project aims to combine the benefits of wild-type T7 RNA polymerase, which has high efficiency and low cost, with the ability of mutant T7 RNA polymerases to...
- This federal Project Grant award of $459,250.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to develop a systematic approach for detecting regulatory RNAs and their functional motifs based on RNA-protein interactions. The key research objectives include: Investigating whether RNA regulates the genomic occupancies of chromatin-associated proteins (CAPs). Employing an...
- The National Institute of General Medical Sciences (NIGMS) awarded a $298,530 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Epigenter, LLC in Providence, RI. The grant supports the development of "Epigenetic Editor Therapeutics" - a novel approach to modulating gene expression without altering the DNA sequence. The project aims to create recombinant, self-delivering epigenetic editor proteins that can be taken up by cells and targeted to...
- This $306,788 federal Project Grant was awarded on September 30, 2025 by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports the development of advanced probe technologies for ultrasensitive, quantitative RNA imaging using Hybridization Chain Reaction (HCR) amplification methods. The research aims to enable multiplexed, high-resolution imaging of gene expression patterns in highly autofluorescent...
- The U.S. National Institute of General Medical Sciences (NIGMS), through the Biomedical Research and Research Training federal grant program (CFDA 93.859), awarded a $432,834 Project Grant to the Board of Regents of the University of Nebraska on April 15, 2025. The grant supports the development of an "enzyme-free, label-free quantitative microarray technology" to detect and quantify target nucleic acids, such as microRNA, with high sensitivity down to the attomolar (10^-18 M) range....
- The federal Project Grant award of $673,600.00 from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) aims to develop an RNA-based sensor that can detect changes in both mRNA and miRNA within living cells and mouse models. The objective is to create a programmable, synthetic biology tool that can identify diseased cells based on their RNA profiles and trigger...
- This federal Project Grant award for $440,000.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports a research program at Northwestern University that investigates how RNA modifications, known as the epitranscriptome, regulate the translation of mRNA into proteins and how this interplay affects cell responses to stress. The research aims to fill gaps in understanding of how...
- This $383,482 Project Grant, awarded on June 6, 2025 by the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research), aims to develop SPINSEQ, an innovative RNA sequencing platform capable of precise and accurate transcriptomic analysis. The project, conducted by Electronic Biosciences, Inc., a small biotechnology company in San Diego, California, focuses on maintaining RNA integrity and enabling improved detection of RNA modifications through advanced sequencing...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), funded under the Biomedical Research and Research Training program (CFDA 93.859), supports the development and commercialization of the AlidaBio EpiPlex V2 assay. This platform aims to provide researchers with a comprehensive method for simultaneously detecting and quantifying the three most prevalent RNA modifications: N6-methyladenosine (m6A), inosine (I), and pseudouridine (Ps). The $1,146,785 award, with a performance period from August 2025 to July 2027, will enable the awardee, Alida Biosciences Inc., to leverage engineered RNA modification-specific binders and enzymatic conversion techniques to pull down and barcode modified RNA fragments for next-generation sequencing and analysis. The expected outcome is the full commercial launch of the AlidaBio EpiPlex V2 assay, providing researchers conducting RNA sequencing with a comprehensive tool for detecting, localizing, and quantifying these critical RNA modifications, which play crucial roles in cellular processes and disease.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.1m | 8/12/25 |