Project Grant R44DK141289

This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $278,224 to Sonomotion Inc. to develop a novel non-invasive treatment called Burst Wave Lithotripsy (BWL) for fragmenting large kidney stones. The key objectives are to: (1) develop a compact low-frequency (~200 kHz) transducer capable of generating high-pressure pulses to fragment 10-20 mm stones; (2) investigate a two-stage BWL approach using both low and high frequencies to optimally fragment stones to < 2 mm fragments; and (3) evaluate the safety and effectiveness of this BWL approach in pre-clinical in vitro and in vivo porcine studies. The expected outcome is a safe and effective BWL treatment ready for clinical trials, with the potential to address 98% of kidney stone sizes without surgery.