This National Science Foundation (NSF) Division of Computer and Network Systems Project Grant award totaling $839,998 to Michigan State University supports the development of a novel wireless optoelectronic implant system for closed-loop control of bi-hormone (insulin and glucagon) secretion from genetically modified islet organoids. The goal is to create an implantable, wireless, and battery-free device that can precisely regulate hormone levels to manage type 1 diabetes. The project involves...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to develop a pregnancy-specific mode for the FDA-approved Ilet Bionic Pancreas automated insulin delivery system. The $725,628 award, beginning on September 10, 2024, will fund a 5-week crossover trial in 20 non-pregnant individuals with type 1 and type 2 diabetes to optimize the Ilet...
The federal Project Grant award R43DK137616 for $275,766.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award funds Biosurfaces Inc., a for-profit medical device company, to develop and evaluate an implantable, electrospun cell chamber device loaded with human pancreatic islets. The device aims to provide an immune-protected environment to support...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support the development of novel dual agonist drug candidates, termed Molecular Artificial Pancreas Systems (MAPS), to treat diabetics with impaired awareness of hypoglycemia (IAH). The $929,940 award will fund manufacturing, formulation, efficacy validation, and safety studies on 3 lead MAPS...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $990,990 Project Grant under CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research to Integrated Medical Sensors Inc. (IMS), a minority-owned small disadvantaged business in Irvine, CA. The objective is to optimize the manufacturing and quality framework for IMS's CGM+ continuous glucose monitoring platform, which uses miniaturized semiconductor-based electrochemical sensors to measure...
The National Science Foundation (NSF) has awarded a $360,000 Project Grant under the CFDA Program "Computer and Information Science and Engineering" to the University of Texas at Austin (UT Austin) and Michigan State University for a collaborative research project. The goal of this 4-year project is to develop a novel framework for continuous, precise, and closed-loop control of bi-hormone (insulin or glucagon) secretion from genetically modified islet organoid grafts using tiny,...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $324,998 to Minutia Inc. to develop advanced stem cell-derived pancreatic islet cell technologies for treating type 1 diabetes. The key products and services to be delivered under this award include: Assessing the impact of genetically modifying stem cell-derived islet cells to be more...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $345,650 to Reshape Lifesciences Inc., a small business joint venture, for research on a novel Diabetes Targeted Dual Neuromodulation (TDN) Therapy. The objective is to validate the feasibility of using an implantable pulse generator system to modulate the vagus nerve and improve glycemic...
The National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems awarded a $450,000 Project Grant to the Texas A&M Engineering Experiment Station (Tees) to develop an injectable, grain-of-rice size glucose biosensor for continuous blood sugar monitoring. The key products or services to be provided under this 3-year grant include: Developing an injectable glucose biosensor comprised of a self-cleaning membrane and a near-infrared fluorescence...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $875,714 to the University of Washington to develop and validate a toolbox of AI-designed mini-proteins (epibinders) that can control the differentiation of pluripotent stem cells into functional pancreatic islet tissue. The project aims to enhance the efficiency and functional maturation of stem...