Project Grant R44DK103398

Acatechol, Inc. was awarded a $274,982 National Science Foundation (NSF) Small Business Innovation Research (SBIR) Phase I grant to develop an innovative anti-infective coating for Foley catheters. The project aims to create a hybrid coating that combines biofilm-repellent and antimicrobial properties to provide prolonged resistance against pathogen colonization and catheter-associated urinary tract infections (CAUTIs). This work is being conducted under the NSF Technology, Innovation, and...

This Project Grant, awarded by the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), aims to develop a unique antimicrobial vascular catheter to prevent catheter-related bloodstream infections (CRBSI). The $272,702 award, effective September 1, 2023, with a completion date of February 29, 2024, will support research and development efforts to create an intravascular catheter with inherent long-lasting antiseptic properties. The...

This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to develop a catheter end cap with an antimicrobial luminal insert to reduce the risk of bloodstream infections in hemodialysis patients. The $591,844 award to Allvivo Vascular, Inc. will fund the development of the "Gatekeeper Antimicrobial Barrier Cap (GCAP)" that acts...

This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award provides $305,000 to Novaurum Biosciences Incorporated to develop a novel mammalian cell-based nano-biological coating for implantable medical devices. The project aims to address the critical issue of implant-related infections, which cost the U.S. healthcare system over $8.6 billion annually. The proposed nano-biological coating is designed to inhibit biofilm formation and...

The National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), awarded a $350,000 Project Grant to Karios Technologies LLC to develop TissueShield, a novel single-use, ready-to-use, sterile, dual-chamber, dual-syringe sprayable hydrogel for preventing post-surgical cardiac adhesions. TissueShield is a 3-component polymer system that can be easily sprayed directly onto the heart, forming a robust anti-adhesion layer within seconds. The...

This Project Grant award from the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) supports the development of a remote monitoring system to reduce infections among patients undergoing peritoneal dialysis (PD). The $550,000 award to The Johns Hopkins University aims to develop a medical device that can enable high-frequency, real-time monitoring of cellular biomarkers in dialysate to quickly detect PD-associated infections. The...

The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $1,938,467 Project Grant under the "Discovery and Applied Research for Technological Innovations to Improve Human Health" program (CFDA 93.286) to Brigham & Women's Hospital to develop a catheter placement system for adaptive image-guided pelvic brachytherapy. The project aims to create a teleoperated catheter insertion manipulator combined with a fiber-optic shape-sensing stylet to provide...

This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $208,154 to The General Hospital Corporation (doing business as Massachusetts General Hospital) to evaluate the potential of a novel Antimicrobial Blue Light (ABL) emitting envelope (ABL-ENV) to combat cardiac implantable electronic device (CIED) infections. The key products or services to be delivered under this award...

This $256,000 National Science Foundation project grant supports the development of an automated chest tube to prevent clotting. Circulatech LLC will design and prototype a novel chest tube that proactively manages fluid flow within the catheter lumen to flush and drain the tube, reducing blood clot formation. Through a process called "dilutional coagulopathy," the tube will use sterile saline or anticoagulants to reduce thrombosis in the drainage space rather than relying on...

Corveus Medical, Inc. was awarded a $255,841 Project Grant from the National Science Foundation under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084) to develop an extravascular bipolar catheter for targeted nerve ablation with minimal collateral damage to surrounding tissues. The grant aims to support the design and prototyping of a minimally invasive, catheter-delivered venous procedure for performing extravascular greater splanchnic nerve ablation. The proposed catheter...