Project Grant R44AR079960
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $594,000 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to Poly Orth International to develop a 3D-printed "Skin and Bone Integrated Pylon" (SBIP) for direct skeletal attachment of limb prostheses. The research aims to demonstrate the feasibility and safety of this novel prosthetic technology, which can potentially benefit patients who...
- This $624,165.00 Project Grant was awarded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research Program (CFDA 93.865), to support the development of a novel prosthetic ankle joint device named the Passive Dorsiflexing Ankle Prosthesis (PDAP). The objective is to validate the PDAP prototype experimentally and add terrain adaptation capabilities to transform it into the PDAP Terrain...
- This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Cooperative Agreement award to Reselute, Inc. provides $998,921 to develop a novel implantable orthopedic medical device and procedure to reduce recovery duration and infection risks associated with severe traumatic fractures of the long bones. The project aims to advance a 3D-printed, antibiotic-releasing intramedullary nail to improve upon current standard-of-care implants that are prone to...
- This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $314,362 to Reselute, Inc. to develop the ReselutionTM Hindfoot Intramedullary Nail. The goal of this project is to create a combination implant that integrates structural support with sustained local antibiotic delivery to prevent infections while stabilizing fractures and fusions in...
- This Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $640,236 to investigate the influence of prosthetic foot stiffness on outcomes for individuals with transtibial bone-anchored limbs (BALs). The overarching goal is to determine how prosthetic foot stiffness impacts loading-related outcomes such as mobility, physical function, and quality of life for...
- The National Science Foundation (NSF) Directorate for Engineering (ENG) awarded a $249,697 Project Grant to The Research Foundation For The State University Of New York, doing business as Stony Brook University, to develop a novel prosthetic robot for individuals with lower limb amputation. The key objectives of this 4-year project are to: Develop a wearable motion capture system using inertial measurement units (IMUs) to reconstruct and predict human gait during daily life activities outside of...
- This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will fund research on the impact of prosthesis osseointegration on postural control in individuals with transfemoral amputation. The $473,906 award, effective December 1, 2024 through March 31, 2026, will support a cross-sectional study comparing 15 individuals with osseointegrated...
- The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $366,700 Project Grant under the "Discovery and Applied Research for Technological Innovations to Improve Human Health" (CFDA 93.286) program to The Leland Stanford Junior University. The project aims to develop specifications for wearable devices that can act as haptic sensory prostheses to replace lost touch sensation due to conditions like amputation, diabetes, and stroke. The key objectives are to:...
- This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) provides $830,712 to Peer Technologies PLLC to commercialize a novel lumbar interbody fusion technology. The project, titled "SMART CAVITY CREATOR DRILL FOR LUMBAR INTERBODY FUSION: DIRECT TO PHASE II," aims to develop a sensor-enabled, articulated drill bit ("Smart Cavity...
- This Cooperative Agreement award from the National Institute of Neurological Disorders and Stroke (CFDA 93.279 - Drug Use and Addiction Research Programs) provides $3,242,520.00 to the University of Pittsburgh to quantify the safety and feasibility of a fully implanted spinal cord stimulation (SCS) system to treat phantom limb pain (PLP) in people with lower-limb amputation. The primary goal is to restore sensation in the missing limb and reduce PLP, which affects over 70% of people with...
VALIDATING ESTABLISHMENT OF FUNCTIONAL SAFETY IN SKIN INTERFACE WITH DEEPLY POROUS TRANSCUTANEOUS PYLON FOR DIRECT SKELETAL ATTACHMENT OF LIMB PROSTHESES - RESEARCH EFFORTS OF THE POLY-ORTH INTERNATIONAL DEMONSTRATED FEASIBILITY OF THE NOVEL "RESIDUUM-INTEGRATION PROSTHETIC TECHNOLOGY" TO BE USED IN DIRECT SKELETAL ATTACHMENT OF LIMB PROSTHETICS. THE TECHNOLOGY INCLUDES A "SKIN AND BONE INTEGRATED PYLON" (SBIP), WHICH CONNECTS THE RESIDUUM WITH EXTERNAL LIMB PROSTHESIS AND CAN BE ESPECIALLY BENEFICIAL FOR PATIENTS WHO CAN NOT USE TRADITIONAL SOCKET ATTACHMENT OF THE PROSTHESES. AS HISTOPATHOLOGY ANALYSIS AFTER THE STUDY WITH SMALL AND LARGE ANIMALS HAS DEMONSTRATED, THE SBIP IS INTEGRATED NOT ONLY WITH THE RESIDUAL BONE, BUT ALSO WITH THE RESIDUUM'S SKIN MINIMIZING THE RISK OF INFECTION AND SECONDARY TRAUMA. THE INVESTIGATORS DEVELOPED AN OPTIMAL POROUS TITANIUM MATRIX AND DESIGN OF THE SKIN AND BONE INTEGRATED PYLON TO MAXIMIZE THE INGROWTH OF BONE AND SKIN CELLS OF THE RESIDUUM TO THE SBIP WITHOUT COMPROMISING STRENGTH OF THE IMPLANTED DEVICE. THE TECHNOLOGICAL STUDY ON THE PROCESS OF MANUFACTURING OF THE COMPOSITE POROUS STRUCTURE ENFORCED WITH A PERMEABLE INTERNAL FRAME. PARAMETERS OF THE SBIP'S SPECIFICATION ARE PROTECTED BY THE US PATENT #8257435. DURING THE PROPOSED TRANSLATIONAL PRE-CLINICAL STUDY, THE ANIMAL TRIALS WILL BE CONDUCTED ACCORDING TO THE FDA REQUIREMENTS TO ENSURE SMOOTH TRANSLATION TO THE TRIALS IN HUMANS. IT WILL INCLUDE LARGE ANIMALS (PIGS) AND THE IMPLANTATION PERIOD UP TO 22 MONTHS.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 12/16/24 | ||
| Not listed | $0 | 4/19/23 | ||
| Not listed | $731.6k | 8/17/22 | ||
| Not listed | $731.6k | 8/17/22 | ||
| Not listed | $731.6k | 8/17/22 |