Project Grant R43TR005303
- This federal Project Grant award of $348,848 was provided by the National Center for Advancing Translational Sciences (NCATS) under the CFDA program 93.350 - National Center for Advancing Translational Sciences. The grant aims to diversify the cyclization positions in mRNA display libraries, a method of rapidly generating large protein-peptide binding datasets and discovering novel peptide therapeutics. The funded work will leverage a new approach called Segmented In Vitro Translation (SIVT)...
- This Project Grant award from the National Center for Advancing Translational Sciences (NCATS), under CFDA Program 93.350, provides $329,272 to Capienda Biotech, LLC to develop a high-throughput kinetic system for small-molecule drug discovery. The goal is to create an innovative instrument that can rapidly characterize the binding kinetics of compounds targeting human cyclin-dependent kinases, which are important oncology targets. This will help medicinal chemists identify drug candidates...
- This federal Project Grant award, totaling $850,740 and provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), aims to significantly expand fluorescence spectral multiplexing in tissue imaging. The key objectives are to: Develop a 56-color panel of semiconducting polymer dots (PDots) with narrow absorption and emission bands to enable 56-plex imaging for deep immune profiling of cells in tissue samples....
- This $306,872 Project Grant award from the National Center for Advancing Translational Sciences (CFDA 93.350) supports the development of a 3D printed integrated sample preparation and chromatography platform for proteomics research at Millennial Materials & Devices Inc., a small disadvantaged business located in Stony Brook, New York. The project aims to fabricate customized 3D printed carbon microbead stationary phase materials and additive manufacturing tools to create an integrated...
- This federal Project Grant award, valued at $375,337.00 and provided by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), supports the development of photothermal mid-infrared single molecule super-localization microscopy to track the intracellular processes governing mRNA release from lipid nanoparticle (LNP) formulations. The goal is to provide...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $330,076 to Trestle Optics LLC, a small disadvantaged business located in Irvine, California. The award supports the development of a novel photothermal microscopy platform integrated with spatial light interference imaging. This innovative instrument is designed to enable non-destructive profiling and mapping of...
- This federal Project Grant award of $436,001 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to create a novel spatial transcriptomics platform that increases accessibility and efficiency. The key products and services to be delivered include: Developing a spatial transcriptomics platform using a simple filter array format that increases sequencing depth per spatial barcode, enabling more data per...
- This $302,671 federal Project Grant awarded on August 2, 2025 by the National Institute of General Medical Sciences (CFDA 93.859 Biomedical Research and Research Training program) to Andson Biotech Inc. aims to develop an innovative real-time mass spectrometry platform for in-process monitoring and cell state analysis of advanced cell therapies. The project seeks to address the challenges of variable quality and efficacy in cell therapies by enabling real-time measurement and control of critical...
- This federal Project Grant award of $349,566 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of a Spotting-Free Nano-Oscillator Array (SFNOA) technology for high-throughput, label-free quantification of ligand binding kinetics to transmembrane proteins in their native states. The key products and services delivered through this award include: Integration of innovative technologies...
- The federal Project Grant award of $350,000 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) is supporting the development and demonstration of a novel enzyme-based, single-molecule protein sequencing system by Electronic Biosciences, Inc. This innovative platform leverages enzyme-driven processing and sequencing of individual proteins and peptides, combined with advanced bioinformatics, to achieve high...
This federal Project Grant award of $322,388.00 from the National Center for Advancing Translational Sciences (NCATS), under CFDA 93.350, will support the "Production of Stimulated Emission-Encoded Beads for Large Molecular Library Generation" at Spectral Therapeutics, Inc. in California. The project aims to develop an optical-encoded library technology capable of encoding diverse molecular libraries and decoding them instantaneously during assay readout. The technology will involve synthesizing libraries on polymeric beads encoded with optical particles that emit narrow-bandwidth light upon excitation, allowing each bead to be uniquely identified. This novel encoding platform will be validated through the microfluidic droplet-templated production of encoded beads and testing of on-bead binding assays using positive control ligands and known targets. The project is expected to be completed by Jul 31, 2026.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $322.4k | 7/29/25 |