This Project Grant award from the National Institutes of Health (NIH) Office of Research Infrastructure Programs (CFDA 93.351 - Research Infrastructure Programs) provides $294,543 to Objective Biotechnology, Inc. to develop and evaluate a machine vision-guided robotic system for automating microinjection procedures on Drosophila melanogaster (fruit fly) embryos.
The key products and services to be delivered under this award include:
- Evaluating the efficacy and generalizability of the automated microinjection system across a range of Drosophila experimental parameters, such as genetic backgrounds, injection locations, injectant compositions, and operational variables.
- Innovating the machine learning algorithms to address identified failure modes in the automated microinjection process, including detecting clustered embryos and mitigating pipette clogging.
This award aims to eliminate the need for manual, operator-dependent microinjection procedures, which are time-consuming and require significant training. The automated robotic system is expected to perform microinjections 6 times faster than human technicians. The project period runs from Sep 1, 2024 to Aug 31, 2025.
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