Project Grant R43NS145855
Award Date 8/13/25
Completion Date 6/30/26
Dollars Obligated $500K
Federal Agency
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
San Diego, CA 92121, USA
Similar Awards
- This $490,501 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853), supports Janusq LLC, a startup biotech company spun out of Case Western Reserve University, in developing a peptide-based therapy called HV-3 for the treatment of Huntington's disease (HD). The key objectives of this 16-month project are to: (1) perform preliminary safety and toxicity...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $195,000 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the University of Colorado-Denver. The 2-year grant, effective from April 1, 2025 to March 31, 2027, will support research to evaluate the feasibility of determining the mechanism of action of small molecule splicing modulators. These modulators have shown promise for efficiently modulating...
- This federal Project Grant award of $345,114, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to develop a high-throughput small molecule screening platform to reduce the endogenous levels of the MSH3 protein for a potential disease-modifying therapy for Huntington's disease (HD). The research initiative focuses on leveraging a multi-faceted approach,...
- The University of South Florida (USF) received a $141,650 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) on September 8, 2023. The research project, titled "Nanoscopic Membrane Modulations Induced by Nanoscale Oligomers", will investigate the effects of nanoscale oligomers of the mutant Huntingtin protein on the properties of lipid...
- This $2,503,949 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research at Rockefeller University aimed at discovering therapeutic targets for neurological diseases. The project utilizes new techniques and concepts to study the fundamental mechanisms of brain disorders, focusing on how differences in cell-specific RNA regulation contribute to...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $450,313 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to The Johns Hopkins University to develop high-throughput screening (HTS) assays to identify activators of the nemo-like kinase (NLK) protein. The goal is to find small molecule compounds that can lower mutant huntingtin (mHTT) protein levels as a potential therapeutic approach for Huntington's...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $773,607 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to The Johns Hopkins University. The grant supports the development of brain-penetrant, histone evicting anthracycline drugs for the treatment of diffuse midline glioma (DMG), an aggressive and incurable form of pediatric brain cancer. The researchers are working to develop novel anthracycline...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $1,830,581 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program to The Johns Hopkins University. The grant supports in-depth characterization of the mechanism of action of a new macrocycle molecule called RAPIREON, which selectively activates the nuclease activity of the IRE1 protein in the unfolded protein response (UPR) pathway....
- This federal Project Grant award in the amount of $426,650 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The funding supports research by Trustees of Tufts College, doing business as Tufts University, to develop a hybrid strategy for efficiently deriving region-specific neural cell populations, including oligodendrocytes and neural crest progenitors,...
- The federal Project Grant award of $485,442 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant will fund the development of "ZippinCarriers", a novel delivery platform designed to transport oligonucleotide (ON) therapeutics and other molecules across the blood-brain barrier to treat neurological conditions. The award will enable the...
This Project Grant award of $499,988 from the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853, Extramural Research Programs in the Neurosciences and Neurological Disorders, supports research by Origami Therapeutics, Inc. to uncover the molecular targets of their potential brain-penetrant small molecule therapeutic ORI-113 for treating Huntington's disease. The goal is to selectively eliminate toxic mutant Huntingtin protein and reduce aggregates while sparing the essential wild-type Huntingtin protein, which could offer an effective oral treatment for Huntington's disease patients. The research project will run from August 2025 through June 2026.
Generated 10/21/25, 6:16 AM
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $500.0k | 8/13/25 |