Project Grant R43HL186922

The National Heart, Lung, and Blood Institute awarded Resuscitation Innovations LLC $396,098 on August 10, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop and test an adjustable-pressure impedance threshold device for cardiac arrest resuscitation and post-resuscitation care.

The recipient will refine the design of the Adjustable Pressure for Emergency Care (APEC) device, a dual-setting airway device with selectable cracking pressures of -6 and -12 centimeters of water that enable field adjustment between cardiac arrest resuscitation and spontaneous breathing recovery states. Bench testing will confirm performance specifications, pressure-flow characteristics, dead space volume, and durability. Hemodynamic and respiratory performance will be evaluated in a porcine model of cardiac arrest and post-return-of-spontaneous-circulation spontaneous breathing.

The current FDA-cleared impedance threshold device (ResQPod) uses a fixed cracking pressure that limits adaptability across patient conditions. The APEC device addresses this limitation by allowing rapid, on-the-fly pressure adjustment: higher pressures (-10 to -16 centimeters of water) augment circulation during cardiopulmonary resuscitation, while lower settings (-6 centimeters of water) reduce breathing effort in recovering or hypotensive patients.

This is a Phase I SBIR project. Performance will take place in Edina, Minnesota from August 10, 2026, through July 31, 2027. The assistance type is a Project Grant.