Project Grant R43HL179155
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), aims to investigate new strategies for preventing immune rejection of hematopoietic stem cell grafts in transplantation. The $725,971 award, with a performance period from August 15, 2025 to May 31, 2030, will fund research at the University of California, San Diego (UCSD) to explore the use of gene editing to silence mismatched human leukocyte...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) will support research at New York University School of Medicine to investigate the use of HLA eplet mismatches (EMM) as a biomarker for immunologic risk in heart transplant recipients. The $819,532 award aims to leverage existing datasets and patient cohorts to model the association between EMM and immunoreactivity, which could help guide personalized immunosuppression...
- This $2,024,340 Project Grant was awarded on August 15, 2025 by the National Heart Lung and Blood Institute (NHLBI), part of the National Institutes of Health, under the Cardiovascular Diseases Research federal grant program (CFDA 93.837). The grant supports a multi-year research effort at Boston Children's Hospital to optimize outcomes for hematopoietic stem cell transplantation (HCT), an essential treatment for high-risk non-malignant and malignant hematologic diseases. The research project...
- This federal Project Grant award, totaling $753,813 and provided by the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), supports research to develop novel machine learning techniques for predicting cardiovascular outcomes in patients with clonal hematopoiesis of indeterminate potential (CHIP). The key goals are to use cardiac MRI imaging and genomic data to: 1) Develop a machine learning model to accurately identify CHIP patients and predict their risk...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $165,672 to New York University School of Medicine to conduct research aimed at increasing heart transplant (HT) volume in the United States. The key objectives are to: Investigate the impact of donor risk factors, such as coronary artery disease, left ventricular dysfunction, and older age, on post-HT outcomes using European and U.S. registry data. This...
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) is focused on validating a new model for predicting long-term outcomes in patients with acute graft vs. host disease (GVHD) following allogeneic hematopoietic cell transplantation. The $126,750 award to the Icahn School of Medicine at Mount Sinai will be used to confirm that the Mount Sinai Acute GVHD International Consortium (MAGIC) algorithm probability (MAP) model, which...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $131,211 to The Leland Stanford Junior University to conduct research on high-resolution tracking of T cell differentiation to predict and control alloreactive disease in allogeneic hematopoietic stem cell transplantation (allo-HSCT). The grant, which has a performance period from July 15, 2025 to June 30, 2027, aims to identify alloreactive T cell subsets...
- This Project Grant award of $125,532.00, provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), aims to investigate the disruption of the clonal architecture of human hematopoietic stem cells driven by high-effect somatic and germline genetic variants, and identify the resulting phenotypic changes that lead to impaired stem cell function and increased disease risk with aging. The research will utilize a mitochondrial lineage tracing...
- The University of Utah received a $782,289 project grant award from the National Heart, Lung, and Blood Institute's Cardiovascular Diseases Research program (CFDA 93.837) to develop machine learning models that incorporate donor lung CT images to predict the risk of severe primary graft dysfunction (PGD) in lung transplant recipients. The project aims to leverage a multi-center cohort of lung transplant data to build improved predictive models that fuse donor and recipient clinical data with...
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $641,544 to the University of North Carolina at Chapel Hill to develop enhanced machine learning tools for complex data evaluation and integration in advancing health outcomes related to heart, lung, blood, and sleep (HLBS) disorders. The project aims to: 1) propose novel machine learning methods for adjusting complex confounding...
This Project Grant award of $207,740.00 from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) aims to develop a machine learning model that can predict permissive human leukocyte antigen (HLA) mismatches for hematopoietic stem cell transplants (HCT) using post-transplant cyclophosphamide (PTCY) for graft-versus-host disease (GVHD) prophylaxis. The goal is to improve HCT utilization and outcomes for ethnic minority patients who face disparities in donor availability and transplant success rates due to HLA diversity. The project, conducted by Immunomatics, Inc., will create a Cox proportional hazards neural network model to identify HLA mismatches that do not significantly increase transplant complications, thereby optimizing donor selection and expanding access to HCT for underrepresented patient populations. The award period runs from August 15, 2025 to July 31, 2026.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $207.7k | 8/14/25 |