This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), aims to develop an Optical Sensor-Enabled Endotracheal Tube (OS-ETT) to reduce the risk and incidence of esophageal intubation and unintended extubation. The total funding amount is $506,500.00, awarded on September 1, 2024, with an ultimate completion date of August 31, 2025. The project will demonstrate the feasibility of the OS-ETT by optimizing the LED-photodiode array and signal processing algorithm for vocal cord identification, and evaluating the OS-ETT for vocal cord identification in a live porcine model. After this Phase I project, the subsequent Phase II will develop the image processing screen, conduct GLP testing, and complete validation tests for biocompatibility, sterilization, and packaging, in preparation for a first-in-human clinical study.
Generated 3/18/25, 4:36 AM