Project Grant R43HL172367

Award Date 5/1/24
Completion Date 2/28/25
Dollars Obligated $299K
Federal Grant Program
93.837
Assistance Type
Project Grant
Place of Performance
Pittsburgh, PA 15206, USA
Similar Awards
The federal Project Grant award R33HL171782, provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research Program (CFDA 93.837), will support the continued clinical development of a novel pleural and tracheal sealant. The $381,000 award will fund research activities to define optimal manufacturing, sterilization, and storage conditions for the sealant, as well as further evaluate its long-term safety and efficacy in animal models of pleural...
The National Heart, Lung, and Blood Institute (NHLBI), a division of the National Institutes of Health (NIH), awarded a $506,500 Project Grant under the Cardiovascular Diseases Research federal grant program (CFDA 93.837) to Endolynx Inc. in Jersey City, NJ. The project aims to develop an Optical Sensor-Enabled Endotracheal Tube (OS-ETT) to reduce the risks and costs associated with esophageal intubation and unintended extubation during the ~30 million intubations performed annually in the...
This Project Grant award from the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) aims to develop a modern Electrical Impedance Tomography (EIT) device for monitoring children in the Intensive Care Unit (ICU). The $299,900 award to Goodlife Inventors LLC will fund efforts to (1) generate initial designs for an advanced lightweight EIT belt and (2) assess the technical feasibility of a miniaturized, easier to use EIT core device. If...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), is supporting the development of the Aerosolve Biohelmet - a personal negative pressure device to safely transport and treat patients with highly transmissible respiratory infectious diseases like COVID-19 and influenza. The $842,408 award to Inspire RX LLC will be used to refine the Biohelmet design, conduct performance testing, and deploy the...
The National Heart, Lung, and Blood Institute (NHLBI), under CFDA program 93.837 Cardiovascular Diseases Research, awarded a $1,160,157 Project Grant (R43HL176331) to Liberandum Technologies, Inc. The goal of this 1-year Phase I SBIR project is to develop and test a bidirectional synchronous flow-controlled ventilation system to improve oxygenation and ventilation in patients with acute respiratory distress syndrome (ARDS). This novel ventilation technology aims to reduce ventilator-induced lung...
This $827,682 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research Federal Grant Program (CFDA 93.837) supports a research project aimed at developing a comprehensive imaging approach to characterize lung perfusion in Acute Respiratory Distress Syndrome (ARDS). The key objectives are to utilize dynamic contrast-enhanced (DCE) and dual-energy CT (DECT) imaging to map pulmonary blood flow and volume, as well as electrical...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health (NIH), is funded under the Cardiovascular Diseases Research program (CFDA 93.837). The $807,067 grant will support a research project titled "Novel Physiomarkers of High-Risk Labored Breathing for Advance Warning of Clinical Deterioration". The primary objective is to develop and validate new quantitative respiratory kinematic markers that can predict the onset...
This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant awarded $274,440 to Vine Medical Inc., a for-profit manufacturing company, to develop a proof-of-concept for a self-deploying endotracheal intubation device. The proposed soft robotics system aims to achieve over a 90% first-pass intubation success rate, which would improve patient outcomes and reduce complications during emergency airway management procedures. The device is designed to...
This federal Project Grant award, provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), aims to develop a prototype decision support system to simplify and expand the use of esophageal pressure (Pes) monitoring to personalize and optimize mechanical ventilation. The $295,924 grant awarded to Convergent Engineering, Inc., a medical technology company located in Gainesville, Florida, will fund the creation and evaluation...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) focuses on developing and demonstrating a high-volume manufacturing technology for microfluidic oxygenators to treat respiratory failure. The $294,063 award to Biomembretics, Inc. aims to fabricate injection-molded microfluidic oxygenators as a safer, simpler alternative to extracorporeal membrane oxygenation (ECMO) for respiratory failure patients....

This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), supports the development of RelianceET, a novel endotracheal tube (ETT) design with an improved sealing mechanism to reduce ventilator-associated infections and lung injury for patients.

The $299,101 grant awarded to Respair, Inc. will fund comprehensive testing and evaluation of the RelianceET prototype across adult airway sizes. The project aims to quantify critical safety metrics like leak prevention, tracheal force, and ventilatory pressures to validate the feasibility of the baffle-based sealing mechanism. Additionally, the project will assess insertion and removal forces on a novel 3D-printed airway model to provide comparative data on the performance of the RelianceET versus current ETTs. Completing these milestones will enable Respair to finalize the RelianceET design and prepare for future FDA submission, with the goal of commercializing a safer and more effective critical care ETT.

Generated 4/29/25, 2:01 AM