Project Grant R43HL134439

This R33 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), is supporting the preclinical optimization and manufacturing development of an immunoregulatory tissue-engineered vascular graft (TEVG) device for cardiovascular applications. The $738,356 grant awarded to the University of Pittsburgh aims to perform final in vitro testing, scale-up manufacturing, and in vivo evaluation of the TEVG construct...

The National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research Federal Grant Program (CFDA 93.837), awarded a $595,464 Project Grant to Cerulean Scientific Inc. on September 25, 2024. The funding supports the development and commercialization of Cerulean Scientific's tethered liquid perfluorocarbon (TLP) coating technology for peripheral vascular grafts (PVGs). The key objectives are to evaluate the durability, anti-fouling properties, and thrombogenicity of...

This Project Grant from the National Institutes of Health's National Institute of Biomedical Imaging and Bioengineering will fund research at Hofstra University related to the development of plant-based vascular grafts. With $790,800 in funding over three years from August 2022 to July 2025, the university will pursue tissue engineering techniques to decellularize plant leaves and condition them as scaffolds for vascular grafts. The research aims to create a nonthrombogenic graft that mimics the...

Endoshape, Inc. was awarded a $370,938 project grant from the National Heart, Lung, and Blood Institute of the National Institutes of Health to develop radiopaque shape memory polymers for neurovascular embolotherapy applications. The Cardiovascular Diseases Research program aims to support heart and vascular research, including through competitive research training grants. Under this award, Endoshape will develop new radiopaque shape memory polymer materials incorporated into embolic coils....

This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) aims to develop a new class of biodegradable and elastic vascular grafts for hemodialysis access. The $298,371 award will fund the refinement of graft manufacturing techniques and testing of the grafts in a sheep model to mimic clinical hemodialysis practice. The project seeks to address the high...

This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health (NIH), is for the development of an endovascular prosthetic graft device that integrates nitric oxide (NO)-releasing polymer technology. The goal is to create a device that can reduce the incidence of infection, neointimal proliferation, and thrombosis - the three main clinical complications associated with current endovascular stent grafts. The total funding...

This $647,359 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports the engineering of biomaterials with controlled biomolecule delivery for cardiovascular applications. The key products and services to be delivered include: Efficient and sustainable delivery of microRNA-145 from a novel biomaterial (PVA-CDI immobilized aminated fucoidan, or PCAF) to smooth muscle cells to induce a contractile...

This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research Program (CFDA 93.837) aims to develop an innovative microrobotic drug delivery system for preventing vascular complications in end-stage kidney disease (ESKD) patients. The $703,523 award, granted on May 21, 2025, will support research by the Mayo Clinic Arizona to refine the microrobotic technology for safe and effective endoluminal drug delivery, identify the optimal...

The National Institute of Biomedical Imaging and Bioengineering (NIBIB) has awarded a $2,252,419 Cooperative Agreement under the "Discovery and Applied Research for Technological Innovations to Improve Human Health" program (CFDA 93.286) to the University of North Carolina at Chapel Hill (UNC-CH). The grant funds the development of an innovative vascular conduit device, the Functional Integrated Electrospun (FINE) device, to address the high failure rates of arteriovenous fistulae...

This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) provides $704,672 to Flowpoint Medical Inc. to develop and evaluate an implantable self-sealing needle guide system to improve the safety and reliability of hemodialysis treatments. The key products/services being delivered through this Phase I SBIR project include: (1) refinement of the device's...