Project Grant R43GM165336
- The National Center for Advancing Translational Sciences awarded Goeppert LLC, a Philadelphia-based small disadvantaged business, $350,000 on July 1, 2026, under CFDA 93.350 (National Center for Advancing Translational Sciences) to develop NANO-PAVE, a nanopore-based platform for assessing adeno-associated virus (AAV) capsid quality in gene therapy manufacturing. NANO-PAVE addresses a critical bottleneck in AAV clinical translation: current quality-control assays (ELISA, ddPCR, analytical...
- The National Institutes of Health National Center for Advancing Translational Sciences awarded $306,872 to Endless Vectors Bioscience on September 3, 2026, under the NCATS Program (CFDA 93.350) to develop and validate a cell cycle-dependent replicating adeno-associated virus platform for treating neonatal inborn errors of metabolism. Endless Vectors will assess tissue-specific replication, episomal persistence, and long-term safety and efficacy of the CCRAAV platform in neonatal mouse liver...
- The National Institute of General Medical Sciences awarded the University of Massachusetts Medical School $1,675,000 on May 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to interrogate the roles of truncated and mutated inverted terminal repeat (ITR) sequences in adeno-associated virus (AAV) vectors and their effects on transgene stability through episome formation and host cell genome integration. The project, designated R01GM155648, addresses a critical gap...
- The National Institute of General Medical Sciences awarded $300,001 to Vivid Bioinnovations, PBC on August 4, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop an integrated micro-robotic screening platform for high-throughput chemical reaction optimization and artificial intelligence model training. Vivid Bioinnovations will engineer a scalable platform combining micro-robotic nanoliter droplet dispensing with custom nanowell arrays and matrix-assisted...
- The National Institute of Allergy and Infectious Diseases awarded Neovaxsyn Inc. $300,000 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop a novel recombinant adeno-associated virus (rAAV) production system optimized for gene therapy and vaccine applications. Neovaxsyn will design, generate, and evaluate a baculoviral expression system called OneBacMid that enables rAAV assembly in mammalian cells, aiming to improve both quality and...
- The National Institute of General Medical Sciences awarded The Ohio State University $386,105 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate adeno-associated virus (AAV) biology, genome persistence, and the translation of AAV persistence mechanisms to synthetic gene-delivery substrates. The research addresses three core questions: the fate of AAV genomes across human tissues and the molecular features of episomal AAV; whether...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded Vecgen, Inc. $333,689 on September 1, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to develop and validate a diagnostic tool predicting immune responses to adeno-associated virus (AAV) gene therapies. Vecgen will clone and produce a comprehensive set of AAV vectors carrying FDA-approved gene therapy sequences and establish standardized immunogenicity benchmarks using...
- This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award for $275,000 will support the development of a plasmonic nanopore sensor device for quality control of adeno-associated viruses (AAVs) used in gene therapy. The proposed device will enable accurate characterization of AAV payload (single-stranded DNA, double-stranded DNA, or empty) at low, pre-scale-up concentrations to optimize formulations. The project aims to demonstrate the...
- The National Institute of Neurological Disorders and Stroke awarded The Broad Institute, Inc. $404,282 on May 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to engineer transferrin receptor 1 (TFR1) binding adeno-associated virus (AAV) capsids that evade pre-existing neutralizing antibodies while maintaining central nervous system delivery capability. The funded research addresses a critical barrier to AAV gene therapy for...
- The National Science Foundation Division of Chemical, Bioengineering, Environmental, and Transport Systems awarded the University of Texas at Arlington $300,000 on September 1, 2026, for collaborative research in multimodal nanopore biosensing and nanosieving for upstream quality control of adeno-associated virus gene therapy vectors under the Engineering program (CFDA 47.041). The project will develop an integrated optical-electrical nanopore biosensing platform to detect and quantify...
The National Institute of General Medical Sciences awarded Avagene Therapeutics Inc. $220,958 on September 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to advance an automated manufacturing platform for adeno-associated virus (AAV) gene therapy production. Avagene will develop and demonstrate technical feasibility of Bodhi, a compact, closed incubator platform that integrates AI-powered brightfield and fluorescence microscopy, programmable microenvironments, and sterile fluidics for adherent cell AAV manufacturing. Phase I work focuses on two objectives: validating that the closed incubator meets sterility and environmental stability thresholds, and developing an AI imaging suite that quantifies cell confluence and transfection accuracy with electronic batch record export capability. Deliverables include benchmarking of the system against open bench 2D yields, validated vision analytics, draft standard operating procedures, and a defined pathway to Phase II pilots. The platform is designed to preserve a directly transferable 2D workflow, minimizing standard operating procedure requalification during transition to clinical readiness. Success will reduce iteration cycles, improve reproducibility, and lower per-batch cost for academic research labs, vector core facilities, and emerging biotechnology companies, while supporting cleaner technology transfer toward good manufacturing practice compliance. Performance occurs in Philadelphia, Pennsylvania, with a period of performance through March 14, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $221.0k | 8/21/26 |