The National Institute of General Medical Sciences (NIGMS) awarded a Project Grant totaling $311,168 on Sep 1, 2024 to Accelerated Muscle Biotechnologies Consultants, L.L.C. under the Biomedical Research and Research Training program (CFDA 93.859). The grant will support the development of infrastructure at the Brookhaven National Labs LIX beamline to enable increased access and standardized data quality for muscle small-angle X-ray scattering (MSAXS) experiments. This will allow academic and industry researchers who are not MSAXS experts to utilize the technology for studying sarcomeric protein organization in skeletal and cardiac muscle, including for evaluating the mechanism of action of the FDA-approved drug mavacamten. The project aims to produce MSAXS data comparable to current best practices and establish reproducibility and repeatability metrics to enable wider adoption of the technique across different synchrotron facilities. The lessons learned are expected to generalize to other biological sample types beyond muscle tissue.
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